Sugiura Masaharu, Hirano Keiichi, Kobayashi Shu
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
J Am Chem Soc. 2004 Jun 16;126(23):7182-3. doi: 10.1021/ja049689o.
Three-component reactions of aldehydes, ammonia, and allylboronates were found to provide homoallylic primary amines in high yields with high chemo- and stereoselectivities. A two-step, one-pot, stereoselective synthesis of an uncommon alpha-amino acid, alloisoleucine, was achieved utilizing this reaction.
醛、氨和烯丙基硼酸酯的三组分反应被发现能够以高化学选择性和立体选择性高产率地提供高烯丙基伯胺。利用该反应实现了一种罕见的α-氨基酸——别异亮氨酸的两步一锅法立体选择性合成。
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