Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019, USA.
Org Lett. 2011 Nov 4;13(21):5736-9. doi: 10.1021/ol2022438. Epub 2011 Oct 12.
Convenient methods for the direct conversion of imidazolium salts to the corresponding 2-imidazolone or 2-imino imidazole derivatives have been developed. Treatment of the salt with commercial bleach leads to effective oxidation at C2 and the formation of the corresponding imidazolone. Alternatively, treatment of the salt with an N-chloro amide affords the corresponding protected 2-amino derivative in good yield.
已经开发出将咪唑鎓盐直接转化为相应的 2-咪唑啉酮或 2-亚氨基咪唑衍生物的方便方法。用商业漂白剂处理盐可在 C2 处有效氧化并形成相应的咪唑啉酮。或者，用 N-氯酰胺处理盐可高产率得到相应的保护 2-氨基衍生物。
