Koswatta Panduka B, Lovely Carl J
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington TX 76019-0065.
Tetrahedron Lett. 2010 Jan 6;51(1):164-166. doi: 10.1016/j.tetlet.2009.10.117.
Simple total syntheses of two Leucetta-derived marine alkaloids have been developed using position specific halogen-metal exchange of polyhaloimidazoles to introduce the benzyl substituted sidechains. Introduction of the C2 amine group by lithiation and trapping with tosyl azide provides amines on catalytic hydrogenation, which can be converted to naamidine G and 14-methoxynaamidine G using a procedure described in the literature.
通过多卤代咪唑的位置特异性卤-金属交换来引入苄基取代的侧链，已开发出两种源自白海绵属的海洋生物碱的简单全合成方法。通过锂化并用对甲苯磺酰叠氮捕获来引入C2胺基，在催化氢化时提供胺，使用文献中描述的方法可将其转化为纳米定G和14-甲氧基纳米定G。
