Department of Pediatrics, Ain Shams University, Cairo, Egypt.
Indian Pediatr. 2012 Apr;49(4):277-80. doi: 10.1007/s13312-012-0041-5. Epub 2011 Aug 15.
To evaluate adiponectin levels in children and adolescents with type I diabetes, and their relationship to long term complications.
Cross sectional.
Tertiary referral hospital, Cairo, Egypt.
Thirty children and adolescents with type I diabetes mellitus, classified into complicated and non-complicated and compared to 10 healthy age and sex matched subjects as a control group.
All children underwent anthropometric measurements, neurological assessment, fundus examination, echocardiography and assays of HbA1c, creatinine, 24-hr urinary protein, and serum adiponectin.
Relationship of serum adiponectin to complications of type I diabetes mellitus, and glucose control.
Serum adiponectin was significantly elevated in complicated diabetes (10.3 ± 5.9 pg/dL) as compared to the controls (6.5 ± 3.7 pg/dL) (P<0.01), and correlated directly with HbA1c (P<0.05) and creatinine (P<0.001). Patients with nephropathy showed high values of adiponectin (15.7 ± 3.7 pg/dL).
Elevated adiponectin level in children and adolescents with type I diabetes indicates poor glycemic control and development of complications, especially nephropathy.
评估 1 型糖尿病患儿和青少年的脂联素水平及其与长期并发症的关系。
横断面研究。
埃及开罗的三级转诊医院。
30 名 1 型糖尿病患儿和青少年，分为复杂组和非复杂组，并与 10 名年龄和性别匹配的健康对照组进行比较。
所有患儿均进行了人体测量学测量、神经学评估、眼底检查、超声心动图检查以及糖化血红蛋白 HbA1c、肌酐、24 小时尿蛋白和血清脂联素的检测。
血清脂联素与 1 型糖尿病并发症及血糖控制的关系。
复杂组糖尿病患儿的血清脂联素（10.3 ± 5.9 pg/dL）明显高于对照组（6.5 ± 3.7 pg/dL）（P<0.01），并与 HbA1c（P<0.05）和肌酐（P<0.001）呈正相关。肾病患儿的脂联素水平较高（15.7 ± 3.7 pg/dL）。
1 型糖尿病患儿和青少年中脂联素水平升高表明血糖控制不佳和并发症的发生，尤其是肾病。
