Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Department of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, Gyeonggi-do, South Korea.
Invest Ophthalmol Vis Sci. 2023 Apr 3;64(4):6. doi: 10.1167/iovs.64.4.6.
To evaluate the association between retinal and choroidal thickness and serum and aqueous humor (AH) adiponectin concentrations in patients with diabetic retinopathy (DR).
This prospective study enrolled diabetic patients without DR (group 1, n = 46) and with DR (n = 130). Central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and adiponectin in serum and AH concentrations were compared. For subgroup analysis, the DR group was divided into four subgroups: mild (group 2), moderate (group 3), severe nonproliferative DR (group 4), and panretinal photocoagulation (group 5).
The log-transformed serum and AH adiponectin concentrations in patients with DR (groups 2-5) were higher than in patients without DR (all Ps < 0.001). In addition, serum and AH adiponectin concentrations showed a positive linear correlation with DR severity (P < 0.001 and P = 0.001, respectively). In univariate analysis between serum or AH adiponectin concentrations and CFT or SCT, AH adiponectin significantly correlated with CFT and SCT (all Ps < 0.001). However, serum adiponectin concentration significantly correlated with SCT (P = 0.041) but not with CFT (P = 0.337). In multivariate analysis, AH adiponectin concentration significantly correlated with CFT, but serum adiponectin concentration did not (P = 0.002 and 0.309, respectively). In contrast, serum and AH adiponectin concentrations significantly correlated with SCT (P = 0.048 and 0.041, respectively).
Serum and AH adiponectin concentrations are positively associated with DR development and progression. Additionally, SCT looks related to the serum and AH adiponectin concentrations, whereas CFT looks related to AH adiponectin concentrations.
评估糖尿病视网膜病变（DR）患者的视网膜和脉络膜厚度与血清和房水（AH）脂联素浓度之间的关系。
本前瞻性研究纳入了无 DR（第 1 组，n = 46）和有 DR（n = 130）的糖尿病患者。比较了中央凹视网膜厚度（CFT）、脉络膜下 SCT 和血清及 AH 中的脂联素浓度。对于亚组分析，DR 组分为 4 个亚组：轻度（第 2 组）、中度（第 3 组）、严重非增生性 DR（第 4 组）和全视网膜光凝（第 5 组）。
DR 患者（第 2-5 组）的血清和 AH 脂联素浓度的对数值高于无 DR 患者（均 P < 0.001）。此外，血清和 AH 脂联素浓度与 DR 严重程度呈正相关（均 P < 0.001 和 P = 0.001）。在血清或 AH 脂联素浓度与 CFT 或 SCT 之间的单变量分析中，AH 脂联素与 CFT 和 SCT 显著相关（均 P < 0.001）。然而，血清脂联素浓度与 SCT 显著相关（P = 0.041），但与 CFT 不相关（P = 0.337）。在多变量分析中，AH 脂联素浓度与 CFT 显著相关，但血清脂联素浓度不相关（分别为 P = 0.002 和 0.309）。相反，血清和 AH 脂联素浓度与 SCT 显著相关（分别为 P = 0.048 和 0.041）。
血清和 AH 脂联素浓度与 DR 的发生和进展呈正相关。此外，SCT 与血清和 AH 脂联素浓度相关，而 CFT 与 AH 脂联素浓度相关。
