Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Adv Anat Pathol. 2011 Nov;18(6):450-3. doi: 10.1097/PAP.0b013e318234aad2.
This review discusses the evolution of an emerging dermatologic entity, virus-associated trichodysplasia spinulosa (TS), and its association with the novel human TS polyomavirus. We will describe how this distinct dermatologic diagnosis has arisen from the convergence of strikingly similar histopathologic findings observed across several case reports. The case of virus-associated TS exemplifies how a combination of astute clinicopathologic observation and a well-designed molecular genetic approach can provide insights into the pathogenesis of cutaneous disease.
本文讨论了一种新兴皮肤科疾病——病毒相关性毛发空泡状营养不良（TS）及其与新型人类 TS 多瘤病毒的关联。我们将描述这一独特的皮肤科诊断是如何从几个病例报告中观察到的明显相似的组织病理学发现的趋同演变而来的。病毒相关性 TS 的病例说明了敏锐的临床病理观察和精心设计的分子遗传学方法的结合如何为皮肤疾病的发病机制提供深入了解。
