Kassar Rawan, Chang Janis, Chan An-Wen, Lilly Leslie B, Al Habeeb Ayman, Rotstein Coleman
Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Multi-organ Transplant Program, University Health Network, Toronto, ON, Canada.
Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12702. Epub 2017 May 15.
Trichodysplasia spinulosa (TS) is a rare dermatologic complication associated with the immunosuppressive therapy used in solid organ transplantation. The distinctive clinical manifestation of this condition is spiny follicular papules on the face, ears, extremities, and trunk. Histopathologically, abnormally maturing hair follicles with hyperkeratotic material are noted. The condition is produced by the trichodysplasia spinulosa-associated polyomavirus. Treatment of this condition in the past has entailed a reduction in immunosuppression, topical agents such as cidofovir or retinoids, or oral valganciclovir. Herein, we report a case of generalized TS treated successfully with leflunomide.
棘状毛囊发育不良（TS）是一种与实体器官移植中使用的免疫抑制治疗相关的罕见皮肤病并发症。这种疾病的独特临床表现为面部、耳部、四肢和躯干出现棘状毛囊丘疹。组织病理学上，可见毛囊异常成熟并伴有角化过度物质。该疾病由棘状毛囊发育不良相关多瘤病毒引起。过去，这种疾病的治疗方法包括减少免疫抑制、使用西多福韦或维甲酸等外用药物，或口服缬更昔洛韦。在此，我们报告一例用来氟米特成功治疗的泛发性TS病例。
