一名儿童的棘状毛发发育异常：在皮肤、血清和尿液中鉴定出与棘状毛发发育异常相关的多瘤病毒
Trichodysplasia spinulosa in a child: Identification of trichodysplasia spinulosa-associated polyomavirus in skin, serum, and urine.
作者信息
Chamseddin Bahir H, Tran Bao Anh Patrick D, Lee Eunice E, Pastrana Diana V, Buck Christopher B, Wang Richard C, Kirkorian Anna Yasmine
机构信息
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Dermatology, Howard University Hospital, Washington, District of Columbia.
出版信息
Pediatr Dermatol. 2019 Sep;36(5):723-724. doi: 10.1111/pde.13857. Epub 2019 Jun 12.
A 6-year-old girl with a history of chronic immunosuppression following small bowel and colon transplantation for tufting enteropathy presented with a diffuse, facial-predominant eruption composed of pink-to-skin-colored papules with central white dystrophic spicules. Histology from a punch biopsy and polymerase chain reaction (PCR) from plucked spicules confirmed a diagnosis of trichodysplasia spinulosa (TS). Additional molecular studies identified several strains of the trichodysplasia spinulosa-associated polyomavirus infecting multiple tissues of the patient, confirming the systemic nature of trichodysplasia spinulosa infections.
一名6岁女孩因簇状肠病接受小肠和结肠移植后有慢性免疫抑制病史，出现以面部为主的弥漫性皮疹，由粉红色至肤色丘疹组成，丘疹中央有白色营养不良性棘刺。打孔活检的组织学检查以及拔除棘刺后的聚合酶链反应（PCR）证实诊断为棘状毛发发育异常（TS）。进一步的分子研究发现几种与棘状毛发发育异常相关的多瘤病毒株感染了患者的多个组织，证实了棘状毛发发育异常感染的全身性。
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