Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel.
Cornea. 2011 Dec;30(12):1376-81. doi: 10.1097/ICO.0b013e31821de36f.
Chalazion may be associated with some local and systemic conditions. We studied the prevalence of various conditions among patients with chalazion.
A retrospective observational case-control study of all the members who were diagnosed with chalazion in the Central District of Clalit Health Services in Israel (years 2000-2008; n = 9119) and 9119 age- and gender-matched controls randomly selected from the district members. We calculated the prevalence of various ocular, systemic, and demographic conditions as risk factors for chalazion.
Demographically, a significant (P < 0.0001) tendency to develop chalazion was found in the population of lower socioeconomic class, in the population living in urban areas, in young females (10-29 years), in older men (older than 60 years), and in non-Ashkenazi Jews. The following risk factors of chalazion were statistically significant: blepharitis [odds ratio (OR), 6.2], rosacea (OR, 2.9), gastritis (OR, 1.4), anxiety (OR, 1.5), irritable bowel syndrome (OR, 1.7), and smoking (OR, 1.2). Diabetes (OR, 0.8) and hypothyroidism (OR, 0.8) were significantly less prevalent among chalazion patients.
Some systemic conditions are significantly more prevalent and some are significantly less prevalent among patients with chalazion. Better understanding of the pathophysiological association between those diseases and chalazion may help in its treatment and prevention.
霰粒肿可能与某些局部和全身状况有关。我们研究了患有霰粒肿的患者中各种情况的患病率。
对以色列克拉利特卫生服务中心中部地区（2000-2008 年）所有被诊断为霰粒肿的成员（n=9119）以及从该地区成员中随机选择的 9119 名年龄和性别匹配的对照进行了回顾性观察性病例对照研究。我们计算了各种眼部、全身和人口统计学状况的患病率，作为霰粒肿的危险因素。
从人口统计学上看，社会经济地位较低、居住在城市地区、年轻女性（10-29 岁）、老年男性（60 岁以上）和非阿什肯纳兹犹太人的人群中，霰粒肿的发病趋势明显（P<0.0001）。霰粒肿的以下危险因素具有统计学意义：睑缘炎（比值比[OR]，6.2）、酒渣鼻（OR，2.9）、胃炎（OR，1.4）、焦虑（OR，1.5）、肠易激综合征（OR，1.7）和吸烟（OR，1.2）。糖尿病（OR，0.8）和甲状腺功能减退（OR，0.8）在霰粒肿患者中明显较少见。
一些全身性疾病在霰粒肿患者中更为常见，而一些疾病则明显较少见。更好地了解这些疾病与霰粒肿之间的病理生理关联，可能有助于其治疗和预防。
