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Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.Bcl-2对正常及恶性淋巴细胞中肌醇1,4,5-三磷酸受体和钙信号的调控：癌症治疗的潜在新靶点
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Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP.三磷酸肌醇受体 1 型和 2 型单通道特性受三磷酸肌醇、钙离子和 ATP 的差异调节。
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Spatial-temporal patterning of Ca signals by the subcellular distribution of IP and IP receptors.通过 IP 和 IP 受体的亚细胞分布对 Ca 信号进行时空模式化。
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Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating.通透钙离子对单肌醇 1,4,5-三磷酸受体通道门控的调节作用。
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本文引用的文献

1
Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels.氧化还原调节的 InsP3R 钙释放通道配体募集的异质阈值。
Biophys J. 2010 Jul 21;99(2):407-16. doi: 10.1016/j.bpj.2010.04.034.
2
Dynamic regulation of IP3 receptor clustering and activity by IP3.肌醇三磷酸（IP3）对IP3受体聚集和活性的动态调节
Channels (Austin). 2009 Jul-Aug;3(4):226-32. doi: 10.4161/chan.3.4.9247. Epub 2009 Jul 12.
3
Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.肌醇三磷酸（InsP3）使肌醇三磷酸受体聚集，从而重新调整其对肌醇三磷酸和钙离子（Ca2+）的调节。
Nature. 2009 Apr 2;458(7238):655-9. doi: 10.1038/nature07763.
4
Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal [corrected] Ca2+release.单个肌醇三磷酸受体Ca2+释放通道的分级募集与失活：对量子化[校正后]Ca2+释放的影响
J Physiol. 2006 Jun 15;573(Pt 3):645-62. doi: 10.1113/jphysiol.2006.109504. Epub 2006 Apr 27.
5
Regulation by Ca2+ and inositol 1,4,5-trisphosphate (InsP3) of single recombinant type 3 InsP3 receptor channels. Ca2+ activation uniquely distinguishes types 1 and 3 insp3 receptors.单个重组3型肌醇1,4,5-三磷酸（InsP3）受体通道受Ca2+和肌醇1,4,5-三磷酸（InsP3）的调节。Ca2+激活是1型和3型InsP3受体的独特区别。
J Gen Physiol. 2001 May;117(5):435-46. doi: 10.1085/jgp.117.5.435.
6
Amplitude histograms can identify positively but not negatively coupled channels.幅度直方图可以识别正向耦合通道，但不能识别负向耦合通道。
J Neurosci Methods. 2000 Mar 15;96(2):105-11. doi: 10.1016/s0165-0270(99)00189-2.
7
Single-channel properties in endoplasmic reticulum membrane of recombinant type 3 inositol trisphosphate receptor.重组3型肌醇三磷酸受体内质网膜中的单通道特性
J Gen Physiol. 2000 Mar;115(3):241-56. doi: 10.1085/jgp.115.3.241.
8
Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.通过对Ca2+抑制的配体调节实现1,4,5-三磷酸肌醇[纠正为三磷酸]对三磷酸肌醇[纠正为三磷酸]受体Ca2+通道的激活
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15821-5. doi: 10.1073/pnas.95.26.15821.
9
Single-channel kinetics, inactivation, and spatial distribution of inositol trisphosphate (IP3) receptors in Xenopus oocyte nucleus.非洲爪蟾卵母细胞核中三磷酸肌醇（IP3）受体的单通道动力学、失活及空间分布
J Gen Physiol. 1997 May;109(5):571-87. doi: 10.1085/jgp.109.5.571.

InsP3R channel gating altered by clustering?

作者信息

Vais Horia, Foskett J Kevin, Mak Don-On Daniel

机构信息

Department of Physiology, University of Pennsylvania Perleman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

出版信息

Nature. 2011 Oct 12;478(7368):E1-2; discussion E2-3. doi: 10.1038/nature10493.

DOI:10.1038/nature10493
PMID:21993761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3273963/
Abstract
摘要