Mak Don-On Daniel, Foskett J Kevin
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Cell Calcium. 2015 Jul;58(1):67-78. doi: 10.1016/j.ceca.2014.12.008. Epub 2014 Dec 18.
As an intracellular Ca(2+) release channel at the endoplasmic reticulum membrane, the ubiquitous inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) plays a crucial role in the generation, propagation and regulation of intracellular Ca(2+) signals that regulate numerous physiological and pathophysiological processes. This review provides a concise account of the fundamental single-channel properties of the InsP3R channel: its conductance properties and its regulation by InsP3 and Ca(2+), its physiological ligands, studied using nuclear patch clamp electrophysiology.
作为内质网膜上的一种细胞内钙离子释放通道，普遍存在的肌醇1,4,5-三磷酸（InsP3）受体（InsP3R）在调节众多生理和病理生理过程的细胞内钙离子信号的产生、传播和调节中起着关键作用。本综述简要介绍了InsP3R通道的基本单通道特性：其电导特性以及通过核膜片钳电生理学研究的InsP3和Ca(2+)对其的调节、其生理配体。
