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Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.内质网中的肌醇1,4,5-三磷酸受体：单通道视角
Cell Calcium. 2015 Jul;58(1):67-78. doi: 10.1016/j.ceca.2014.12.008. Epub 2014 Dec 18.
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ER-luminal [Ca] regulation of InsP receptor gating mediated by an ER-luminal peripheral Ca-binding protein.内质网腔[Ca2+]对 InsP 受体门控的调节作用是由内质网腔外周 Ca2+结合蛋白介导的。
Elife. 2020 May 18;9:e53531. doi: 10.7554/eLife.53531.
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Regulation by Ca2+ and inositol 1,4,5-trisphosphate (InsP3) of single recombinant type 3 InsP3 receptor channels. Ca2+ activation uniquely distinguishes types 1 and 3 insp3 receptors.单个重组3型肌醇1,4,5-三磷酸（InsP3）受体通道受Ca2+和肌醇1,4,5-三磷酸（InsP3）的调节。Ca2+激活是1型和3型InsP3受体的独特区别。
J Gen Physiol. 2001 May;117(5):435-46. doi: 10.1085/jgp.117.5.435.
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Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal [corrected] Ca2+release.单个肌醇三磷酸受体Ca2+释放通道的分级募集与失活：对量子化[校正后]Ca2+释放的影响
J Physiol. 2006 Jun 15;573(Pt 3):645-62. doi: 10.1113/jphysiol.2006.109504. Epub 2006 Apr 27.
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Inositol (1,4,5)-trisphosphate (InsP3)-gated Ca channels from cerebellum: conduction properties for divalent cations and regulation by intraluminal calcium.来自小脑的肌醇（1,4,5）-三磷酸（InsP3）门控钙通道：二价阳离子的传导特性及腔内钙的调节
J Gen Physiol. 1994 Nov;104(5):821-56. doi: 10.1085/jgp.104.5.821.
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Inositol trisphosphate receptor Ca2+ release channels.肌醇三磷酸受体钙离子释放通道
Physiol Rev. 2007 Apr;87(2):593-658. doi: 10.1152/physrev.00035.2006.
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Novel model of calcium and inositol 1,4,5-trisphosphate regulation of InsP3 receptor channel gating in native endoplasmic reticulum.天然内质网中钙和肌醇1,4,5-三磷酸调节肌醇三磷酸受体通道门控的新型模型
Biol Res. 2004;37(4):513-9. doi: 10.4067/s0716-97602004000400004.
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Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP.三磷酸肌醇受体 1 型和 2 型单通道特性受三磷酸肌醇、钙离子和 ATP 的差异调节。
J Physiol. 2012 Jul 15;590(14):3245-59. doi: 10.1113/jphysiol.2012.228320. Epub 2012 Apr 30.
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Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.Bcl-2对正常及恶性淋巴细胞中肌醇1,4,5-三磷酸受体和钙信号的调控：癌症治疗的潜在新靶点
Biochim Biophys Acta. 2014 Oct;1843(10):2205-10. doi: 10.1016/j.bbamcr.2014.03.008. Epub 2014 Mar 15.
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ITPRs/inositol 1,4,5-trisphosphate receptors in autophagy: From enemy to ally.自噬中的肌醇三磷酸受体（ITPRs）/肌醇1,4,5-三磷酸受体：从敌人到盟友
Autophagy. 2015;11(10):1944-8. doi: 10.1080/15548627.2015.1083666.
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Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP-InsP Isomers in Plant Signaling.拓展肌醇焦磷酸工具箱：PP-InsP异构体在植物信号传导中的立体选择性合成及应用
Angew Chem Int Ed Engl. 2025 Sep 1;64(36):e202507058. doi: 10.1002/anie.202507058. Epub 2025 Jul 31.
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Modeling traveling calcium waves in cellular structures.模拟细胞结构中的钙波传播
J Comput Neurosci. 2025 Apr 2. doi: 10.1007/s10827-025-00898-2.
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Phosphorylation of Bok at Ser-8 blocks its ability to suppress IPR-mediated calcium mobilization.博克蛋白（Bok）第8位丝氨酸的磷酸化会阻碍其抑制内质网应激反应（IPR）介导的钙动员的能力。
Cell Commun Signal. 2025 Jan 14;23(1):27. doi: 10.1186/s12964-024-02008-8.
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The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca transport in the pathogenesis of diseases.线粒体相关内质网膜（MAMs）与疾病发病机制中钙转运的相关性。
Acta Pharmacol Sin. 2025 Feb;46(2):271-291. doi: 10.1038/s41401-024-01359-9. Epub 2024 Aug 8.
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Agonist-Induced Ca Signaling in HEK-293-Derived Cells Expressing a Single IP Receptor Isoform.激动剂诱导表达单一 IP 受体亚型的 HEK-293 衍生细胞中的 Ca 信号转导。
Cells. 2024 Mar 22;13(7):562. doi: 10.3390/cells13070562.
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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.《药理学简明指南 2023/24 年版》：离子通道。
Br J Pharmacol. 2023 Oct;180 Suppl 2(Suppl 2):S145-S222. doi: 10.1111/bph.16178.
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Understanding IPR channels: From structural underpinnings to ligand-dependent conformational landscape.理解 IPR 通道：从结构基础到配体依赖的构象景观。
Cell Calcium. 2023 Sep;114:102770. doi: 10.1016/j.ceca.2023.102770. Epub 2023 Jun 22.
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Modeling of Ca transients initiated by GPCR agonists in mesenchymal stromal cells.间充质基质细胞中由G蛋白偶联受体激动剂引发的钙瞬变建模。
BBA Adv. 2021 Apr 21;1:100012. doi: 10.1016/j.bbadva.2021.100012. eCollection 2021.
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Viewing Ca-binding sites in the inositol trisphosphate receptor.观察肌醇三磷酸受体中的钙结合位点。
Cell Calcium. 2023 Mar;110:102697. doi: 10.1016/j.ceca.2023.102697. Epub 2023 Jan 27.
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Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity.Bcl-2的疏水裂缝与BH4结构域之间的变构串扰对肌醇1,4,5-三磷酸受体活性的调控
Explor Target Antitumor Ther. 2022;3(3):375-391. doi: 10.37349/etat.2022.00088. Epub 2022 Jun 28.
本文引用的文献
1
Single-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributions.肌醇三磷酸受体的单分子追踪揭示了不同的运动性和分布。
Biophys J. 2014 Aug 19;107(4):834-45. doi: 10.1016/j.bpj.2014.05.051.
2
Ion channels of the nuclear membrane of hippocampal neurons.海马神经元核膜的离子通道
Hippocampus. 2014 Jul;24(7):869-76. doi: 10.1002/hipo.22276. Epub 2014 Apr 25.
3
Structural organization of signalling to and from IP3 receptors.IP3 受体信号转导的结构组织。
Biochem Soc Trans. 2014 Feb;42(1):63-70. doi: 10.1042/BST20130205.
4
Contribution of Ca2+ release channels to hippocampal synaptic plasticity and spatial memory: potential redox modulation.钙释放通道对海马突触可塑性和空间记忆的贡献：潜在的氧化还原调节。
Antioxid Redox Signal. 2014 Aug 20;21(6):892-914. doi: 10.1089/ars.2013.5796. Epub 2014 Mar 11.
5
Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.细胞内钙通道：三磷酸肌醇受体。
Eur J Pharmacol. 2014 Sep 15;739:39-48. doi: 10.1016/j.ejphar.2013.10.074. Epub 2013 Dec 1.
6
Isolating nuclei from cultured cells for patch-clamp electrophysiology of intracellular Ca(2+) channels.从培养细胞中分离细胞核用于细胞内钙通道的膜片钳电生理学研究。
Cold Spring Harb Protoc. 2013 Sep 1;2013(9):880-4. doi: 10.1101/pdb.prot073056.
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Patch-clamp electrophysiology of intracellular Ca2+ channels.细胞内钙离子通道的膜片钳电生理学
Cold Spring Harb Protoc. 2013 Sep 1;2013(9):787-97. doi: 10.1101/pdb.top066217.
8
Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.由串联的同源和异源亚基组装的功能性肌醇 1,4,5-三磷酸受体。
J Biol Chem. 2013 Oct 11;288(41):29772-84. doi: 10.1074/jbc.M113.502203. Epub 2013 Aug 16.
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Single-particle cryo-EM of calcium release channels: structural validation.钙离子释放通道的单颗粒冷冻电镜结构解析：结构验证。
Curr Opin Struct Biol. 2013 Oct;23(5):755-62. doi: 10.1016/j.sbi.2013.06.003. Epub 2013 Jul 5.
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Comparison of models for IP3 receptor kinetics using stochastic simulations.使用随机模拟比较 IP3 受体动力学模型。
PLoS One. 2013 Apr 10;8(4):e59618. doi: 10.1371/journal.pone.0059618. Print 2013.
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