Laboratoire de Chimie des Polymères Organiques, 16 Av. Pey Berland, F-33607 Pessac Cedex 9, France.
Macromol Rapid Commun. 2011 Nov 1;32(21):1722-8. doi: 10.1002/marc.201100459. Epub 2011 Sep 14.
Degradable dendrimer-like PEOs were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 kg · mol(-1) was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (≈2 kg · mol(-1)), as monitored by (1)H NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.
采用具有可裂解缩酮基团的原创 ABC 型支化剂，通过基于环氧乙烷的阴离子开环聚合（AROP）和聚氧化乙烯（PEO）链末端的支化的迭代发散方法，设计了可降解的树枝状大分子型 PEO。以这种方式获得了第七代树枝状大分子型 PEO，其具有 192 个外围羟基，摩尔质量为 446 kg·mol-1。通过（1）H NMR、SEC 和 MALDI-TOF 质谱以及原子力显微镜（AFM）监测，这些树枝状支架在酸性条件下成功地进行了化学降解，形成了低摩尔质量（≈2 kg·mol-1）的线性 PEO 链。
