College of Pharmacy and Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada.
Chembiochem. 2011 Nov 25;12(17):2540-2. doi: 10.1002/cbic.201100577. Epub 2011 Oct 12.
Getting into a transition state: Glycosyltransferases retain a critical role in glycobiology. The design of potent glycosyltransferase inhibitors may be facilitated by considering the mechanistic evidence presented by Davies and Davis and co-workers that strengthens the case that retaining glycosyltransferases function through a single front-side, S(N)i-type mechanism.
糖基转移酶在糖生物学中仍起着关键作用。考虑到 Davies 和 Davis 及其同事提出的具有说服力的机制证据，可能会促进设计有效的糖基转移酶抑制剂，该证据进一步证实了通过单一前侧 S（N）i 型机制保留糖基转移酶功能的观点。
