Goodman W K, McDougle C J, Price L H, Riddle M A, Pauls D L, Leckman J F
Yale University, School of Medicine, Department of Psychiatry, New Haven, CT.
J Clin Psychiatry. 1990 Aug;51 Suppl:36-43; discussion 55-8.
It seems unlikely that a solitary disturbance in serotonin function can fully account for the pathophysiology of obsessive compulsive disorder. The authors propose that some forms of obsessive compulsive disorder, e.g., obsessive compulsive disorder with a history of Tourette's syndrome, may involve a relative or absolute derangement in both brain serotoninergic and dopaminergic systems. A role for dopamine in the pathophysiology of obsessive compulsive disorder is supported by a review of the preclinical and clinical evidence. Additional studies are needed to more directly evaluate dopamine function in patients with obsessive compulsive disorder.
血清素功能的单一紊乱似乎不太可能完全解释强迫症的病理生理学。作者提出，某些形式的强迫症，例如有抽动秽语综合征病史的强迫症，可能涉及大脑血清素能和多巴胺能系统的相对或绝对紊乱。对临床前和临床证据的综述支持了多巴胺在强迫症病理生理学中的作用。需要更多研究来更直接地评估强迫症患者的多巴胺功能。
