Tezcan Didem, Tümkaya Selim
İzzet Baysal Research and Training Hospital, Department of Psychiatry, Bolu, Turkey.
Pamukkale University Medicine Faculty, Department of Psychiatry, Denizli, Turkey.
Noro Psikiyatr Ars. 2018 Dec;55(4):370-375. doi: 10.5152/npa.2017.20571. Epub 2018 Nov 20.
It has been theorized that endophenotype models will help to understand the etiology of heterogeneous brain disorders such as obsessive-compulsive disorder (OCD). In this study, it was aimed to determine whether "situational awareness" impairments which can be defined as partially naturalistic working memory deficits, are an endofenotype for OCD.
In this study, situational awareness (SA) task performances of 67 OCD patients, 50 their unaffected first-degree relatives, and 41 healthy controls who matched with regard to sex, age and years of education were measured to investigate endophenotypes in OCD. For this purpose, a visuospatial working memory test was used.
As a result, the relatives showed a task performance between patients with OCD and control group in both SA1 and SA2 tasks. Patients with OCD performed significantly worse than control group on SA1 single and dual task. On the other hand, there were no significant differences between relatives and patients of any SA assessment.
These results indicated that poor situational awareness may be a candidate endophenotype for OCD. Early perceptual dysfunctions such as poor performance on SA1 task can mediate the genetic risk for OCD.
有理论认为，内表型模型将有助于理解诸如强迫症（OCD）等异质性脑部疾病的病因。在本研究中，旨在确定可定义为部分自然主义工作记忆缺陷的“情境意识”损害是否为强迫症的一种内表型。
在本研究中，测量了67名强迫症患者、50名其未受影响的一级亲属以及41名在性别、年龄和受教育年限方面相匹配的健康对照者的情境意识（SA）任务表现，以研究强迫症的内表型。为此，使用了一项视觉空间工作记忆测试。
结果显示，亲属在SA1和SA2任务中的表现介于强迫症患者和对照组之间。强迫症患者在SA1单任务和双任务中的表现明显比对照组差。另一方面，在任何SA评估中，亲属与患者之间均无显著差异。
这些结果表明，情境意识差可能是强迫症的一种潜在内表型。诸如SA1任务表现差等早期感知功能障碍可能介导强迫症的遗传风险。
