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度洛西汀致抑郁症患者肝损伤。

Duloxetine-induced liver injury in patients with major depressive disorder.

机构信息

Department of Psychiatry, Catholic University of Daegu School of Medicine, Daegu, Korea.

出版信息

Psychiatry Investig. 2011 Sep;8(3):269-71. doi: 10.4306/pi.2011.8.3.269. Epub 2011 Aug 10.

DOI:10.4306/pi.2011.8.3.269
PMID:21994516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3182394/
Abstract

Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also induce liver injury in cases without those risk factors. We recommend that clinicians should monitor liver function carefully following duloxetine treatment.

摘要

度洛西汀是一种平衡的 5-羟色胺和去甲肾上腺素再摄取抑制剂。已知患有先前存在的肝脏疾病或慢性酒精使用的患者会发生度洛西汀引起的肝损伤。然而，我们已经发现，即使没有这些危险因素，度洛西汀也可能导致肝损伤。我们建议临床医生在使用度洛西汀治疗后应仔细监测肝功能。

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本文引用的文献

1
Cholestatic jaundice induced by duloxetine in a patient with major depressive disorder.度洛西汀致重症抑郁障碍患者胆汁淤积性黄疸
Psychiatry Investig. 2010 Sep;7(3):228-30. doi: 10.4306/pi.2010.7.3.228. Epub 2010 Aug 30.
2
Hepatic effects of duloxetine-I: non-clinical and clinical trial data.度洛西汀的肝脏效应-I：非临床和临床试验数据。
Curr Drug Saf. 2008 May;3(2):132-42. doi: 10.2174/157488608784529189.
3
The hepatic safety profile of duloxetine: a review.度洛西汀的肝脏安全性概况：综述
Expert Opin Drug Metab Toxicol. 2008 Mar;4(3):281-5. doi: 10.1517/17425255.4.3.281.
4
Drug-induced liver injury: review article.药物性肝损伤：综述文章。
Dig Dis Sci. 2007 Oct;52(10):2463-71. doi: 10.1007/s10620-006-9472-y. Epub 2007 Mar 16.
5
Duloxetine for patients with diabetic peripheral neuropathic pain: a 6-month open-label safety study.度洛西汀用于糖尿病性周围神经病理性疼痛患者：一项为期6个月的开放标签安全性研究。
Pain Med. 2006 Sep-Oct;7(5):373-85. doi: 10.1111/j.1526-4637.2006.00207.x.
6
Case report: fulminant hepatic failure involving duloxetine hydrochloride.病例报告：涉及盐酸度洛西汀的暴发性肝衰竭
Clin Gastroenterol Hepatol. 2006 Jul;4(7):912-7. doi: 10.1016/j.cgh.2006.04.018. Epub 2006 Jun 22.
7
Mechanisms of drug-induced liver injury.药物性肝损伤的机制。
AAPS J. 2006 Feb 3;8(1):E48-54. doi: 10.1208/aapsj080106.
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