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劳拉西泮作为药物性肝损伤的一个病因

Lorazepam as a Cause of Drug-Induced Liver Injury.

作者信息

Arai Toshio, Kogi Kazutoyo, Honda Yuki, Suzuki Takao, Kawai Koji, Okamoto Masako, Fujioka Takahiro, Murata Nobuhiro

机构信息

Department of Internal Medicine, Uenohara Municipal Hospital, Uenohara-shi, Japan.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Tochigi, Japan.

出版信息

Case Rep Gastroenterol. 2018 Aug 31;12(2):546-550. doi: 10.1159/000492209. eCollection 2018 May-Aug.

DOI:10.1159/000492209
PMID:30283291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6167696/
Abstract

Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admission. The clinical presentation and pathologic findings in the liver were consistent with drug-induced liver injury. After cessation of lorazepam, treatment with Stronger neo-minophagen C and ursodeoxycholic acid was started, and his liver injury resolved after 59 days. This case must serve as a warning to physicians to be aware of the possibility of unexpected liver injury caused by lorazepam.

摘要

劳拉西泮是一种苯二氮䓬衍生物，在全球范围内用于治疗焦虑症和失眠症。一名51岁的日本男性因肝功能障碍入院，其眼睛和皮肤发黄且伴有瘙痒。他在此次入院前约5个月服用过劳拉西泮。肝脏的临床表现和病理检查结果与药物性肝损伤相符。停用劳拉西泮后，开始使用强力新（Stronger neo-minophagen C）和熊去氧胆酸进行治疗，59天后其肝损伤得到缓解。该病例必须警示医生，要意识到劳拉西泮可能导致意想不到的肝损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8945/6167696/b5852e7f7828/crg-0012-0546-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8945/6167696/fc6014d16066/crg-0012-0546-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8945/6167696/b5852e7f7828/crg-0012-0546-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8945/6167696/fc6014d16066/crg-0012-0546-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8945/6167696/b5852e7f7828/crg-0012-0546-g02.jpg

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