Division of Clinical Pathology, University Hospitals, Geneva, Switzerland.
Division of Gastroenterology and Hepatology, University Hospitals, Geneva, Switzerland.
Viruses. 2009 Sep;1(2):126-143. doi: 10.3390/v1020126. Epub 2009 Aug 11.
The persistent infection with hepatitis C virus is a major cause of chronic liver disease worldwide. However, the morbidity associated with hepatitis C virus widely varies and depends on several host-related cofactors, such as age, gender, alcohol consumption, body weight, and co-infections. The objective of this review is to discuss three of these cofactors: steatosis, insulin resistance and oxidative stress. Although all may occur independently of HCV, a direct role of HCV infection in their pathogenesis has been reported. This review summarizes the current understanding and potential molecular pathways by which HCV contributes to their development.
丙型肝炎病毒的持续感染是全球慢性肝病的主要病因。然而，丙型肝炎病毒相关发病率差异很大，取决于多种宿主相关的合并因素，如年龄、性别、饮酒、体重和合并感染。本综述的目的是讨论其中三个合并因素：脂肪变性、胰岛素抵抗和氧化应激。尽管所有这些因素都可能独立于 HCV 发生，但已有报道称 HCV 感染在其发病机制中发挥直接作用。本综述总结了目前对 HCV 导致这些疾病发展的潜在分子途径的认识。
