Division of Virology, Department of Medical Microbiology, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany; E-Mail:
Viruses. 2009 Dec;1(3):678-88. doi: 10.3390/v1030678. Epub 2009 Nov 4.
The WU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens by shotgun sequencing. Intriguingly, viral genome has been detected in 0.4% to 11.5% of respiratory tract specimens from children with respiratory disease. The levels of co-infection with established respiratory viruses were in the range between 30.8% and 91.7%. Moreover, some studies report detection of WUPyV in stool or serum. So far, WUPyV infections can not be distinguished from other viral infections by means of clinical symptoms. Respiratory tract disease like pneumonia or bronchitis is frequently observed in patients harbouring WUPyV. Detection of viremia suggests systemic infections. However, the available data do not prove WUPyV to be a human pathogen. Further investigations are necessary.
WU 多瘤病毒（WUPyV）是最近通过鸟枪法测序在呼吸道标本中发现的一种新型多瘤病毒科成员。有趣的是，在患有呼吸道疾病的儿童的呼吸道标本中，病毒基因组的检出率为 0.4%至 11.5%。与已建立的呼吸道病毒的合并感染率在 30.8%至 91.7%之间。此外，一些研究报告称在粪便或血清中检测到 WUPyV。到目前为止，通过临床症状无法将 WUPyV 感染与其他病毒感染区分开来。患有 WUPyV 的患者常出现肺炎或支气管炎等呼吸道疾病。病毒血症的检测提示存在全身感染。然而，现有数据并不能证明 WUPyV 是人类病原体。还需要进一步的研究。
