Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
Viruses. 2010 Feb;2(2):468-502. doi: 10.3390/v2020468. Epub 2010 Feb 1.
Covalent modification with polyethylene glycol (PEG), a non-toxic polymer used in food, cosmetic and pharmaceutical preparations for over 60 years, can profoundly influence the pharmacokinetic, pharmacologic and toxciologic profile of protein and peptide-based therapeutics. This review summarizes the history of PEGylation and PEG chemistry and highlights the value of this technology in the context of the design and development of recombinant viruses for gene transfer, vaccination and diagnostic purposes. Specific emphasis is placed on the application of this technology to the adenovirus, the most potent viral vector with the most highly characterized toxicity profile to date, in several animal models.
聚乙二醇（PEG）的共价修饰，一种在食品、化妆品和药物制剂中使用了超过 60 年的无毒聚合物，可以显著影响蛋白和肽类治疗药物的药代动力学、药理学和毒理学特性。这篇综述总结了 PEG 化和 PEG 化学的历史，并强调了该技术在设计和开发用于基因转移、疫苗接种和诊断目的的重组病毒方面的价值。特别强调了该技术在几种动物模型中对腺病毒的应用，腺病毒是迄今为止最有效的病毒载体，其毒性特征也得到了最充分的描述。
