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抗逆转录病毒联合治疗对 HIV 感染者中 Epstein-Barr 病毒（EBV）基因组负荷的影响。

The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients.

机构信息

Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 65 Stockholm, Sweden.

Gay Men's Health Clinic, Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, SE-118 83 Stockholm, Sweden.

出版信息

Viruses. 2010 Apr;2(4):867-879. doi: 10.3390/v2040867. Epub 2010 Mar 29.

DOI:10.3390/v2040867
PMID:21994658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3185664/
Abstract

We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.

摘要

我们评估了联合抗逆转录病毒治疗（cART）对中度免疫抑制的 HIV-1 患者宿主控制 EBV 感染的效果。20 名 HIV-1 感染者接受了五年的随访，检测外周血淋巴细胞中的 EBV DNA 载量与 HIV-RNA 滴度和 CD4+细胞计数的关系。具有最佳反应的个体，即持续不可检测的 HIV-RNA，其 EBV 载量下降至健康对照水平。HIV-1 控制不佳的个体未能恢复其 EBV 控制。cART 早期启动后 HIV 复制的长期抑制是重建 EBV 免疫控制的前提。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/bbcc1b2bcbdd/viruses-02-00867f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/2f9eb0192fb7/viruses-02-00867f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/d87aa0fd0a68/viruses-02-00867f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/bbcc1b2bcbdd/viruses-02-00867f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/2f9eb0192fb7/viruses-02-00867f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/b3272b4eeca2/viruses-02-00867f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/d87aa0fd0a68/viruses-02-00867f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/668a/3185664/bbcc1b2bcbdd/viruses-02-00867f4.jpg

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