Van Baarle Debbie, Wolthers Katja C, Hovenkamp Egbert, Niesters Hubert G M, Osterhaus Albert D M E, Miedema Frank, Van Oers Marinus H J
Department of Clinical Viro-Immunology, Sanquin Research at CLB, and Department of Hematology, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.
J Infect Dis. 2002 Aug 1;186(3):405-9. doi: 10.1086/341460. Epub 2002 Jul 17.
To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome-related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level.
为了研究爱泼斯坦-巴尔病毒（EBV）载量是否可用于预测获得性免疫缺陷综合征相关非霍奇金淋巴瘤（AIDS-NHL）的发生，我们对1型人类免疫缺陷病毒感染个体的EBV载量进行了纵向测定。外周血单个核细胞（PBMC）中的EBV载量很高，且随时间有相当大的波动，这表明PBMC中的绝对EBV载量不能预测AIDS-NHL的发生。在某些时间点，血清中也可检测到EBV DNA，但水平较低。
