MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, W1T 4JF, UK.
Viruses. 2010 Jun;2(6):1261-1278. doi: 10.3390/v2061261. Epub 2010 May 31.
Cell-to-cell spread of HIV-1 between CD4(+) T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
HIV-1 在 CD4(+) T 细胞之间的细胞间传播发生在称为病毒学突触的多分子结构中。病毒学突触的一个定义特征是病毒组装和出芽在 T 细胞- T 细胞接触部位的极化。最近的工作开始解决病毒蛋白如何靶向病毒学突触以及调节 HIV-1 通过细胞间传播出芽的分子机制。这篇综述讨论了我们对这些过程的现有理解，并考虑了 T 细胞在其他形式的细胞间通讯中的极化如何为 HIV-1 组装和传播提供深入了解。
