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多重任务：充分利用逆转录病毒包膜

Multitasking: Making the Most out of the Retroviral Envelope.

机构信息

Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, England, UK.

Medical Research Council - University of Glasgow Centre for Virus Research, Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, UK.

出版信息

Viruses. 2010 Aug;2(8):1571-1576. doi: 10.3390/v2081571. Epub 2010 Aug 2.

DOI:10.3390/v2081571
PMID:21994694
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3185736/
Abstract

Evasion of the host's immune system is a required step for the establishment of viral infection. In this article, we discuss the recent findings of Heidmann and colleagues demonstrating that some retroviruses possess an immune suppressive (IS) domain "encrypted" within their envelope glycoprotein that is required to establish a successful infection in immunocompetent hosts [1].

摘要

逃避宿主的免疫系统是病毒感染建立所必需的步骤。在本文中，我们讨论了 Heidmann 及其同事的最新发现，表明一些逆转录病毒在其包膜糖蛋白内具有一个免疫抑制（IS）结构域，该结构域是在免疫功能正常的宿主中建立成功感染所必需的[1]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/3185736/df75187433c6/viruses-02-01571f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/3185736/df75187433c6/viruses-02-01571f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/3185736/df75187433c6/viruses-02-01571f1.jpg

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本文引用的文献

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Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses.逆转录病毒在体内感染需要一种免疫逃逸毒力因子，这种因子被加密在反转录病毒的包膜蛋白中。
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3782-7. doi: 10.1073/pnas.0913122107. Epub 2010 Feb 8.
2
Human immunodeficiency virus, restriction factors, and interferon.人类免疫缺陷病毒、限制因子和干扰素。
J Interferon Cytokine Res. 2009 Sep;29(9):569-80. doi: 10.1089/jir.2009.0077.
3
Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.
合胞素A基因敲除小鼠证明了一种融合性、内源性逆转录病毒衍生的包膜基因在胎盘形成中的关键作用。
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32. doi: 10.1073/pnas.0902925106. Epub 2009 Jun 29.
4
Coevolution of endogenous betaretroviruses of sheep and their host.绵羊内源性β逆转录病毒与其宿主的协同进化
Cell Mol Life Sci. 2008 Nov;65(21):3422-32. doi: 10.1007/s00018-008-8500-9.
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Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins.胎盘融合素：逆转录病毒包膜蛋白的融合活性与免疫抑制活性之间的基因分离
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20534-9. doi: 10.1073/pnas.0707873105. Epub 2007 Dec 12.
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PLoS Pathog. 2007 Nov;3(11):e170. doi: 10.1371/journal.ppat.0030170.
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Endogenous retroviruses regulate periimplantation placental growth and differentiation.内源性逆转录病毒调节着床期胎盘的生长和分化。
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