Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Viruses. 2011 Mar;3(3):172-203. doi: 10.3390/v3030172. Epub 2011 Feb 25.
Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of assembly precursors. The sequence and molecular mechanisms of phage assembly have been elucidated by a variety of methods. Differences and similarities of assembly processes in several different groups of bacteriophages are discussed in this review. The general principles of phage assembly are applicable to many macromolecular complexes.
噬菌体作为一个模型系统，被用于研究组装过程已有半个多世纪。形成有感染性的噬菌体颗粒涉及到特定的蛋白质-蛋白质和蛋白质-核酸相互作用，以及组装前体的大构象变化。噬菌体组装的序列和分子机制已通过多种方法得到阐明。本文综述了几种不同噬菌体群体的组装过程的差异和相似之处。噬菌体组装的一般原理适用于许多大分子复合物。
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