Virus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France.
Viruses. 2011 Mar;3(3):254-259. doi: 10.3390/v3030254. Epub 2011 Mar 9.
Retroviruses like HIV-1 and HTLV-1 can be transmitted efficiently by direct contact between infected and target cells. For HIV-1, various modes of cell-to-cell transfer have been reported, including virological synapses, polysynapses, filopodial bridges, and nanotube-like structures. So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1] identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8.
逆转录病毒,如 HIV-1 和 HTLV-1,可以通过受感染细胞和靶细胞之间的直接接触高效传播。对于 HIV-1,已经报道了多种细胞间转移模式,包括病毒学突触、多突触、丝状伪足桥和纳米管样结构。到目前为止,只有突触和生物膜被描述为 HTLV-1 的传播方式。最近,Van Prooyen 等人[1]通过病毒辅助蛋白 p8 诱导的细胞管确定了 HTLV-1 传播的另一种方式。