Department of Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, Geneva 1211, Switzerland.
Viruses. 2011 Sep;3(9):1757-76. doi: 10.3390/v3091757. Epub 2011 Sep 15.
Human immunodeficiency virus 1 (HIV-1) infects T cells, macrophages and dendritic cells and can manipulate their cytoskeleton structures at multiple steps during its replication cycle. Based on pharmacological and genetic targeting of cytoskeleton modulators, new imaging approaches and primary cell culture models, important roles for actin and microtubules during entry and cell-to-cell transfer have been established. Virological synapses and actin-containing membrane extensions can mediate HIV-1 transfer from dendritic cells or macrophage cells to T cells and between T cells. We will review the role of the cytoskeleton in HIV-1 entry, cellular trafficking and cell-to-cell transfer between primary cells.
人类免疫缺陷病毒 1（HIV-1）感染 T 细胞、巨噬细胞和树突状细胞，并在其复制周期的多个步骤中操纵其细胞骨架结构。基于细胞骨架调节剂的药理学和遗传学靶向、新的成像方法和原代细胞培养模型，已经确定肌动蛋白和微管在进入和细胞间转移过程中的重要作用。病毒学突触和包含肌动蛋白的膜延伸可以介导 HIV-1 从树突状细胞或巨噬细胞转移到 T 细胞以及 T 细胞之间的转移。我们将回顾细胞骨架在原代细胞中 HIV-1 进入、细胞运输和细胞间转移中的作用。
