Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria.
J Clin Endocrinol Metab. 2012 Jan;97(1):148-54. doi: 10.1210/jc.2011-2152. Epub 2011 Oct 12.
Sclerostin is produced by osteocytes and inhibits bone formation through the Wnt/β-catenin-signaling pathway. Only limited data are available on circulating sclerostin levels in healthy subjects.
We aimed to evaluate the correlation between sclerostin and physical activity, anthropometric, and biochemical variables.
DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional observational study in 161 healthy adult men and premenopausal women aged 19 to 64 yr (mean age, 44 ± 10).
INTERVENTION(S): There were no interventions.
MAIN OUTCOME MEASURE(S): Serum sclerostin levels were associated with body composition, bone mineral density, physical activity, and various biochemical parameters.
A positive correlation between age and sclerostin in both men (r = 0.37; P < 0.001) and premenopausal women (r = 0.66; P < 0.001) was found. Men had significantly higher sclerostin levels than women (49.8 ± 17.6 vs. 37.2 ± 15.2 pmol/liter; P < 0.001). However, after adjustment for age, bone mineral content (BMC), physical activity, body mass index (BMI), and renal function, sclerostin levels did not differ (P = 0.543). Partial correlation analysis adjusted for age, gender, and kidney function revealed a significant positive correlation between sclerostin levels and BMC, bone mineral density, BMI, and android/gynoid fat and a significant negative correlation with serum osteocalcin and calcium. The most physically active quartile had significantly lower sclerostin levels compared to the least active quartile in a univariate analysis.
In healthy adults, sclerostin serum levels correlate positively with age, BMI, and BMC and negatively with osteocalcin and calcium. Further studies in larger populations are needed to confirm our findings and to better understand their clinical implications.
骨硬化蛋白由骨细胞产生，并通过 Wnt/β-连环蛋白信号通路抑制骨形成。目前仅有有限的数据可用于评估健康受试者的循环骨硬化蛋白水平。
我们旨在评估骨硬化蛋白与身体活动、人体测量学和生化变量之间的相关性。
设计、设置和参与者：我们进行了一项横断面观察性研究，纳入了 161 名年龄在 19 至 64 岁（平均年龄，44±10 岁）的健康成年男性和绝经前女性。
无干预措施。
血清骨硬化蛋白水平与身体成分、骨密度、身体活动和各种生化参数相关。
我们发现，男性（r=0.37；P<0.001）和绝经前女性（r=0.66；P<0.001）的年龄与骨硬化蛋白之间呈正相关。男性的骨硬化蛋白水平显著高于女性（49.8±17.6 比 37.2±15.2 pmol/L；P<0.001）。然而，在调整年龄、骨矿物质含量（BMC）、身体活动、体重指数（BMI）和肾功能后，骨硬化蛋白水平无差异（P=0.543）。经年龄、性别和肾功能调整的偏相关分析显示，骨硬化蛋白水平与 BMC、骨密度、BMI、男性脂肪和女性脂肪呈显著正相关，与血清骨钙素和钙呈显著负相关。在单变量分析中，最活跃的四分位组的骨硬化蛋白水平显著低于最不活跃的四分位组。
在健康成年人中，骨硬化蛋白血清水平与年龄、BMI 和 BMC 呈正相关，与骨钙素和钙呈负相关。需要在更大的人群中进行进一步的研究来证实我们的发现，并更好地理解其临床意义。
