Turoń-Skrzypińska Agnieszka, Mińko Alicja, Rył Aleksandra, Mańkowska Katarzyna, Ciechanowski Kazimierz, Bereda Zuzanna, Rotter Iwona, Dutkiewicz Grażyna
Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, 71-210 Szczecin, Poland.
Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland.
J Clin Med. 2024 Apr 17;13(8):2321. doi: 10.3390/jcm13082321.
Chronic kidney disease is a significant public health issue associated with reduced physical activity. This can lead to mineral and bone disorders and increased levels of inflammatory markers. One innovative solution that can significantly contribute to increasing patient motivation is the combination of physical training with virtual reality technology during haemodialysis sessions. The aim of this study is to comprehensively assess the impact of regular virtual reality-based physical activity on plasma sclerostin and interleukin 6 levels, as well as on physical performance and the level of physical activity in patients undergoing renal replacement therapy through haemodialysis. This study is a prospective cohort study. Patients included in the study were randomly assigned to two groups: the study group and the control group. The study group consisted of patients who were entrusted with the task of conducting training using the prototype of the NefroVR system. The duration of the study period for both the study and control groups was 3 months. One hundred and two (102) patients with stage 5 chronic kidney disease who underwent haemodialysis as a renal replacement therapy participated in the study. Patients from the study group were characterized by higher physical activity compared to the control group. There was a significant difference in the level of IL-6 and SOST between the study and control groups in the second measurement. Regular physical activity, especially using approaches such as virtual reality, contributes to improving physical fitness and overall activity levels in patients undergoing haemodialysis. The study demonstrated that regular exercise may be associated with a reduction in inflammatory parameters and positive effects on bone metabolism in patients undergoing haemodialysis.
慢性肾脏病是一个与身体活动减少相关的重大公共卫生问题。这可能导致矿物质和骨代谢紊乱以及炎症标志物水平升高。一种能够显著提高患者积极性的创新解决方案是在血液透析过程中将体育锻炼与虚拟现实技术相结合。本研究的目的是全面评估基于虚拟现实的定期体育活动对血浆硬化蛋白和白细胞介素6水平的影响，以及对接受血液透析进行肾脏替代治疗的患者的身体机能和身体活动水平的影响。本研究是一项前瞻性队列研究。纳入研究的患者被随机分为两组：研究组和对照组。研究组由负责使用NefroVR系统原型进行训练的患者组成。研究组和对照组的研究周期均为3个月。102例接受血液透析作为肾脏替代治疗的5期慢性肾脏病患者参与了本研究。与对照组相比，研究组患者的身体活动水平更高。在第二次测量中，研究组和对照组之间的IL-6和SOST水平存在显著差异。定期体育活动，尤其是采用虚拟现实等方法，有助于提高接受血液透析患者的身体素质和整体活动水平。该研究表明，定期锻炼可能与接受血液透析患者的炎症参数降低以及对骨代谢的积极影响有关。
