Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, #108, Pyung Dong, Jongro-Ku, Seoul, South Korea 110-746.
J Clin Endocrinol Metab. 2011 Dec;96(12):E2050-4. doi: 10.1210/jc.2011-1857. Epub 2011 Oct 12.
Traditional lipid measures are known to be associated with incident type 2 diabetes.
Our objective was to assess the independent association between lipid profiles and the development of type 2 diabetes in nondiabetic Korean subjects over a 4-yr period.
A total of 5577 Koreans without diabetes who underwent consecutive comprehensive health check-ups annually for 5 yr were enrolled. We measured concentrations of total cholesterol (TC), triglyceride (TG), apolipoprotein B (apoB), apolipoprotein A-I, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) and calculated lipid ratios. The association between incident type 2 diabetes and the initial values for lipid ratios and other lipoprotein components was examined.
Over the course of 4 yr, 330 subjects (5.9%) developed type 2 diabetes. TC, LDL-C, TG, non-HDL, apoB, apoB to apolipoprotein A-I ratio, TC to HDL ratio, TG to HDL ratio, LDL to HDL ratio and apoB to HDL ratio were associated with incident type 2 diabetes in multivariate analysis after adjustment for age and gender. Of these, the ratio of TC to HDL and apoB to HDL showed a significant association with increased risk of type 2 diabetes, compared with other lipoprotein parameters: odds ratio (1.340, 95% confidence interval 1.166-1.538; and 1.338, 95% confidence interval 1.162-1.540), respectively. The odds ratio for the development of type 2 diabetes increased significantly as the tertiles of the baseline ratio of TC to HDL and apoB to HDL increased from the first to the third tertile.
This study suggests that lipid and lipoprotein profiles can be independently associated with later development of type 2 diabetes in nondiabetic Korean adults in a longitudinal analysis.
已知传统的脂质指标与 2 型糖尿病的发病有关。
我们的目的是评估在 4 年内非糖尿病韩国人血脂谱与 2 型糖尿病发病之间的独立相关性。
共纳入 5577 名连续 5 年每年接受全面健康检查的无糖尿病韩国人。我们测量了总胆固醇（TC）、甘油三酯（TG）、载脂蛋白 B（apoB）、载脂蛋白 A-I、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的浓度，并计算了脂质比值。检查了血脂比值和其他脂蛋白成分与新发 2 型糖尿病之间的关联。
在 4 年的过程中，330 名受试者（5.9%）发生了 2 型糖尿病。TC、LDL-C、TG、非 HDL、apoB、apoB 与载脂蛋白 A-I 比值、TC 与 HDL 比值、TG 与 HDL 比值、LDL 与 HDL 比值和 apoB 与 HDL 比值在调整年龄和性别后，在多变量分析中与新发 2 型糖尿病相关。在这些指标中，TC 与 HDL 的比值和 apoB 与 HDL 的比值与 2 型糖尿病的风险增加呈显著相关，与其他脂蛋白参数相比：比值比（1.340，95%置信区间 1.166-1.538；1.338，95%置信区间 1.162-1.540）。随着基线 TC 与 HDL 比值和 apoB 与 HDL 比值的三分位数从第一分到第三分位增加，发生 2 型糖尿病的比值比显著增加。
这项研究表明，在纵向分析中，血脂和脂蛋白谱可与非糖尿病韩国成年人随后发生 2 型糖尿病独立相关。
