School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Org Lett. 2011 Nov 4;13(21):5740-3. doi: 10.1021/ol202251p. Epub 2011 Oct 13.
The lithiation/borylation-protodeboronation of a homoallyl carbamate was applied to the synthesis of (+)-sertraline and (+)-indatraline. Due to the presence of the alkene, significant modifications of the methodology were required (use of 12-crown-4, TMSCl, H(2)O), or a solvent switch to CHCl(3), to achieve high yields and high selectivities.
将偕胺肟的锂化/硼化-脱硼反应应用于(+)-舍曲林和(+)-吲达帕胺的合成。由于烯烃的存在，需要对方法进行重大修改（使用 12-冠-4、TMSCl、H(2)O），或者切换溶剂至 CHCl(3)，以实现高产率和高选择性。
