（+）-新海松内酯的简明形式合成。
Concise formal synthesis of (+)-neopeltolide.
机构信息
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
出版信息
Org Lett. 2011 Nov 4;13(21):5916-9. doi: 10.1021/ol2025718. Epub 2011 Oct 13.
PMID:21995677
Abstract
A concise formal synthesis of (+)-neopeltolide (1) has been accomplished. The synthesis demonstrated high atom efficiency employing only one step of functional group protection. Key steps involved iridium-catalyzed double asymmetric carbonyl allylation, palladium-catalyzed intramolecular alkoxycarbonylation, ruthenium-catalyzed olefin isomerization, and ring-closing metathesis.
摘要
已完成 (+)-neopeltolide（1）的简洁式全合成。该合成采用仅一步的官能团保护，具有很高的原子经济性。关键步骤包括铱催化的不对称双羰基烯丙基化、钯催化的分子内烷氧基羰基化、钌催化的烯烃异构化和闭环复分解。
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