State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Org Biomol Chem. 2011 Feb 21;9(4):984-6. doi: 10.1039/c0ob00971g. Epub 2010 Dec 13.
The total synthesis of cyanolide A has been achieved in 14 steps from commercially available (S)-2-ethyloxirane, exploiting the palladium-catalyzed intramolecular alkoxycarbonylation as the key step to construct the tetrasubstituted cis-tetrahydropyran ring with high stereoselectivity.
从商业可得的 (S)-2-乙氧基环氧乙烷出发，经过 14 步反应，实现了 cyanolide A 的全合成，利用钯催化的分子内烷氧基羰基化反应作为关键步骤，以高立体选择性构建了四取代的顺式四氢吡喃环。
