氰醇酸 A 的全合成。
Total synthesis of cyanolide A.
机构信息
State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China.
出版信息
Org Biomol Chem. 2011 Feb 21;9(4):984-6. doi: 10.1039/c0ob00971g. Epub 2010 Dec 13.
PMID:21152612
Abstract
The total synthesis of cyanolide A has been achieved in 14 steps from commercially available (S)-2-ethyloxirane, exploiting the palladium-catalyzed intramolecular alkoxycarbonylation as the key step to construct the tetrasubstituted cis-tetrahydropyran ring with high stereoselectivity.
摘要
从商业可得的 (S)-2-乙氧基环氧乙烷出发，经过 14 步反应，实现了 cyanolide A 的全合成，利用钯催化的分子内烷氧基羰基化反应作为关键步骤，以高立体选择性构建了四取代的顺式四氢吡喃环。
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