Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato (CE), Brazil.
Nat Prod Res. 2012;26(4):380-6. doi: 10.1080/14786419.2010.545776. Epub 2011 Oct 14.
In this study, the methanol extracts of of Costus cf. arabicus L. were evaluated for antibacterial activity against multiresistant strains of Escherichia coli and Staphylococcus aureus. The antibacterial and modulatory activity of the extracts was assayed by microdilution. The light-enhanced antibacterial activity was assayed by light regimen. The growth of the bacteria tested was not inhibited by the extracts. The minimum inhibitory concentration (MIC) values ranged from 512 to ≥1024 µg·m L(-1). However, the antibiotic activity of the aminoglycosides was synergistically enhanced when these extracts were associated in sub-inhibitory concentrations with the antibiotics. Both extracts showed activity against at two standard bacterial strains. Because of this, we suggest that the ethanol extracts of the stems and leaves of Costus cf. arabicus L. show potential antibacterial, light-induced and synergistic antibiotic activity. With such results, these extracts are proven to be a promising source of antibacterial and modulatory agents.
在这项研究中，评估了多蕊木甲醇提取物对耐多药大肠杆菌和金黄色葡萄球菌的抗菌活性。通过微量稀释法测定提取物的抗菌和调节活性。通过光照方案测定光增强的抗菌活性。测试的细菌的生长不受提取物的抑制。最小抑菌浓度 (MIC) 值范围为 512 至≥1024 µg·mL(-1)。然而，当这些提取物以亚抑制浓度与抗生素联合使用时，氨基糖苷类抗生素的抗生素活性会协同增强。两种提取物均对两种标准细菌菌株表现出活性。因此，我们认为多蕊木茎和叶的乙醇提取物具有潜在的抗菌、光诱导和协同抗生素活性。有了这样的结果，这些提取物被证明是一种有前途的抗菌和调节药物来源。
