移植受者中产生肺炎克雷伯菌碳青霉烯酶菌株的威胁。
A threat of the Klebsiella pneumoniae carbapenemase-producing strains among transplant recipients.
作者信息
Mlynarczyk G, Kosykowska E, de Walthoffen S Walter, Szymanek-Majchrzak K, Sawicka-Grzelak A, Baczkowska T, Pazik J, Durlik M, Ciszek M, Paczek L, Chmura A, Mlynarczyk A
机构信息
Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland.
出版信息
Transplant Proc. 2011 Oct;43(8):3135-6. doi: 10.1016/j.transproceed.2011.08.004.
BACKGROUND
Infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are associated with increased therapeutic failure and mortality. Our laboratory recognized several strains producing KPC, most of which originated from transplantation ward patients.
MATERIALS AND METHODS
All strains of K pneumoniae resistant to at least 1 carbapenem isolated in 2010 were examined for KPC production by disc diffusion and then verified by molecular methods.
RESULTS
All positive strains originated from 7 patients. Six of them were from transplantation wards. None of the KPC-producing strains was isolated from the patient's blood.
CONCLUSIONS
A quick, accurate diagnosis of KPC-producing strains enabled immediate isolation of carriers or infected persons. Isolation prevented spread of dangerous strains among immunocompromised patients and reduced the possibility of serious infections.
背景
产肺炎克雷伯菌碳青霉烯酶（KPC）的肠杆菌科细菌感染与治疗失败率和死亡率增加相关。我们实验室识别出几株产KPC的菌株，其中大部分源自移植病房的患者。
材料与方法
对2010年分离出的所有对至少一种碳青霉烯类耐药的肺炎克雷伯菌菌株进行纸片扩散法检测以确定是否产KPC，随后通过分子方法进行验证。
结果
所有阳性菌株均来自7名患者。其中6名来自移植病房。未从患者血液中分离出产KPC的菌株。
结论
对产KPC菌株进行快速、准确的诊断能够立即隔离携带者或感染者。隔离可防止危险菌株在免疫功能低下的患者中传播，并降低严重感染的可能性。
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