Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Am J Ophthalmol. 2012 Mar;153(3):530-5. doi: 10.1016/j.ajo.2011.08.012. Epub 2011 Oct 11.
To clarify the clinical characteristics of reticular pseudodrusen in Korean patients.
Retrospective, observational, consecutive case series.
A total of 255 eyes of 130 patients diagnosed with reticular pseudodrusen were evaluated. Reticular pseudodrusen were diagnosed by characteristic fundus findings using ophthalmoscopy, color fundus photography with blue-channel examination, near-infrared photography, red-free photography, autofluorescence imaging, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography. Age-related macular degeneration (AMD) was determined by the International Classification and Grading System.
The mean age was 72.6 ± 9.0 years (range, 43 to 92 years). Most reticular pseudodrusen patients had bilateral disease (97.7%), with a female preponderance (86.2%). All 3 patients who showed unilateral reticular pseudodrusen had neovascular AMD in the eye with no reticular pseudodrusen. AMD was found in 183 eyes (71.8 %), among which early AMD was found in 115 eyes (45.1%), geographic atrophy was found in 41 eyes (16.1%), and neovascular AMD was found in 27 eyes (10.6%). The mean age of patients with AMD and with no AMD was 73.7 ± 9.2 years (range, 58 to 92 years) and 69.9 ± 11.7 years (range, 43 to 90 years), respectively, and there was a statistical difference between these 2 groups (P < .05). Classic choroidal neovascularization was found in 13 eyes (48.1%), and occult choroidal neovascularization was found in 14 eyes (51.9%) in the neovascular AMD group.
Reticular pseudodrusen occurs in Koreans, and clinical manifestations of reticular pseudodrusen in Koreans did not differ significantly from those described in white persons. However, our study demonstrated a higher rate of bilaterality compared with those previously reported, and geographic atrophy was found to be associated more commonly with reticular pseudodrusen than with neovascular AMD. Ethnical differences may be associated with these findings, and further studies are required.
阐明韩国患者中网状假性drusen 的临床特征。
回顾性、观察性、连续病例系列。
共评估了 130 名患者的 255 只眼，这些患者被诊断为网状假性 drusen。使用眼底镜、带蓝通道检查的眼底彩色照相、近红外照相、无赤照相、自发荧光成像、荧光素血管造影、吲哚青绿血管造影和谱域光相干断层扫描对网状假性 drusen 进行诊断。年龄相关性黄斑变性（AMD）通过国际分类和分级系统确定。
平均年龄为 72.6 ± 9.0 岁（范围 43 至 92 岁）。大多数网状假性 drusen 患者为双侧疾病（97.7%），女性居多（86.2%）。3 名单侧出现网状假性 drusen 的患者的眼中均存在新生血管性 AMD。183 只眼中发现 AMD（71.8%），其中 115 只眼中存在早期 AMD（45.1%），41 只眼中存在地图样萎缩（16.1%），27 只眼中存在新生血管性 AMD（10.6%）。AMD 患者和无 AMD 患者的平均年龄分别为 73.7 ± 9.2 岁（范围 58 至 92 岁）和 69.9 ± 11.7 岁（范围 43 至 90 岁），两组间存在统计学差异（P<.05）。新生血管性 AMD 组中发现 13 只眼（48.1%）存在经典脉络膜新生血管，14 只眼（51.9%）存在隐匿性脉络膜新生血管。
网状假性 drusen 发生于韩国人群中，韩国患者的网状假性 drusen 临床表现与白人患者无显著差异。然而，与既往报道相比，本研究显示双侧病变的发生率较高，且与新生血管性 AMD 相比，地图样萎缩更常与网状假性 drusen 相关。这些发现可能与种族差异有关，需要进一步研究。
