Department of Pediatrics, Columbia University, New York, NY, USA.
Trends Immunol. 2011 Dec;32(12):582-8. doi: 10.1016/j.it.2011.09.003. Epub 2011 Oct 11.
The airway epithelium possesses many mechanisms to prevent bacterial infection. Not only does it provide a physical barrier, but it also acts as an extension of the immune system through the expression of innate immune receptors and corresponding effectors. One outcome of innate signaling by the epithelium is the production of type I interferons (IFNs), which have traditionally been associated with activation via viral and intracellular organisms. We discuss how three extracellular bacterial pathogens of the airway activate this intracellular signaling cascade through both surface components as well as via secretion systems, and the differing effects of type I IFN signaling on host defense of the respiratory tract.
气道上皮具有许多防止细菌感染的机制。它不仅提供了物理屏障，还通过表达先天免疫受体和相应的效应器，充当免疫系统的延伸。上皮细胞的先天信号传递的一个结果是产生 I 型干扰素 (IFN)，传统上认为 IFN 通过病毒和细胞内生物的激活而产生。我们讨论了三种气道外源性细菌病原体如何通过表面成分以及通过分泌系统激活这条细胞内信号级联，以及 I 型 IFN 信号对呼吸道宿主防御的不同影响。
