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电脉冲给药:肿瘤学的最新进展。

Drug delivery by electropulsation: Recent developments in oncology.

机构信息

CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), 205 route de Narbonne, F-31077 Toulouse, France.

出版信息

Int J Pharm. 2012 Feb 14;423(1):3-6. doi: 10.1016/j.ijpharm.2011.09.038. Epub 2011 Oct 1.

DOI:10.1016/j.ijpharm.2011.09.038
PMID:21996516
Abstract

Electro-permeabilisation allows the free access of polar compounds to the cytoplasm by a reversible alteration of the cell membrane. It is now used in clinics for the eradication of cutaneous solid tumors. New developments predict its future applications for other anti-cancer treatments.

摘要

电穿孔通过可逆地改变细胞膜使极性化合物自由进入细胞质。目前,它被用于临床以消除皮肤实体肿瘤。新的发展预示着它未来在其他抗癌治疗中的应用。

相似文献

1
Drug delivery by electropulsation: Recent developments in oncology.电脉冲给药:肿瘤学的最新进展。
Int J Pharm. 2012 Feb 14;423(1):3-6. doi: 10.1016/j.ijpharm.2011.09.038. Epub 2011 Oct 1.
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Chitosan nanoparticles for melanoma cancer treatment by Photodynamic Therapy and electrochemotherapy using aminolevulinic acid derivatives.壳聚糖纳米粒用于光动力疗法和电化学疗法联合使用氨基酮戊酸衍生物治疗黑色素瘤。
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Metallic nanoparticles: technology overview & drug delivery applications in oncology.金属纳米颗粒:技术概述及在肿瘤学中的药物传递应用。
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Overview of drug delivery and alternative methods to electroporation.药物递送概述及电穿孔的替代方法。
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Transdermal drug delivery by localized intervention.通过局部干预实现经皮给药
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Electroporation for drug and gene delivery in the clinic: doctors go electric.临床中用于药物和基因递送的电穿孔技术:医生开启“电”时代。
Methods Mol Biol. 2008;423:351-9. doi: 10.1007/978-1-59745-194-9_27.
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Application of electroporation gene therapy: past, current, and future.电穿孔基因治疗的应用:过去、现在与未来。
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Electrochemotherapy for primary skin cancer and skin metastasis related to other malignancies.电化学疗法治疗原发性皮肤癌和与其他恶性肿瘤相关的皮肤转移。
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[Electrochemotherapy for tumor and mechanism analysis].[肿瘤的电化学疗法及其机制分析]
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Loading Intracranial Drug-Eluting Reservoirs Across the Blood-Brain Barrier With Focused Ultrasound.通过聚焦超声使颅内药物洗脱储库跨血脑屏障加载。
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Clinical Phase I/II Study: Local Disease Control and Survival in Locally Advanced Pancreatic Cancer Treated with Electrochemotherapy.临床I/II期研究:电化学疗法治疗局部晚期胰腺癌的局部疾病控制和生存情况
J Clin Med. 2021 Mar 22;10(6):1305. doi: 10.3390/jcm10061305.
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Increasing Uptake of Silica Nanoparticles with Electroporation: From Cellular Characterization to Potential Applications.
通过电穿孔提高二氧化硅纳米颗粒的摄取:从细胞表征到潜在应用
Materials (Basel). 2019 Jan 7;12(1):179. doi: 10.3390/ma12010179.
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A Microdosimetric Study of Electropulsation on Multiple Realistically Shaped Cells: Effect of Neighbours.对多个逼真形状细胞进行电脉冲刺激的微剂量学研究:相邻细胞的影响。
J Membr Biol. 2016 Oct;249(5):691-701. doi: 10.1007/s00232-016-9912-3. Epub 2016 Jun 18.
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Imaging Intratumoral Nanoparticle Uptake After Combining Nanoembolization with Various Ablative Therapies in Hepatic VX2 Rabbit Tumors.纳米栓塞联合多种消融疗法后兔VX2肝癌瘤内纳米颗粒摄取的影像学研究
J Biomed Nanotechnol. 2016 Feb;12(2):296-307. doi: 10.1166/jbn.2016.2174.
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The Electroporation as a Tool for Studying the Role of Plasma Membrane in the Mechanism of Cytotoxicity of Bisphosphonates and Menadione.电穿孔作为研究质膜在双膦酸盐和甲萘醌细胞毒性机制中作用的工具
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Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.基因电转移质粒 AMEP,一种整合素靶向治疗,对小鼠 B16 黑色素瘤具有抗肿瘤和抗血管生成作用。
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Different incubation times of cells after gene electrotransfer in fetal bovine serum affect cell viability, but not transfection efficiency.在胎牛血清中进行基因电转染后,细胞的不同孵育时间会影响细胞活力,但不影响转染效率。
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