Dreamz College of Pharmacy, Khilra-Meramesit, Sundernagar-175036, Mandi, HP, India.
Expert Opin Drug Deliv. 2010 Aug;7(8):927-42. doi: 10.1517/17425247.2010.498473.
The targeted delivery of therapeutic agents to tumour cells is a challenge because most of the chemotherapeutic agents distribute to the whole body, which results in general toxicity and poor acceptance by patients and sometimes discontinuation of the treatment. Metallic nanoparticles have been used for a huge number of applications in various areas of medical treatment. Metallic nanoparticles are emerging as new carrier and contrast agents in cancer treatment. These metallic nanoparticles have been used for imaging of tumour cells by means of active and passive targeting. Recent advances have opened the way to site-specific targeting and drug delivery by these nanoparticles.
This review summarizes the mechanisms of passive and active targeted drug delivery by metallic nanoparticles and their potential use in cancer theranostics.
The reader will gain information on the development of tumour cells, advantages of modern methods of cancer treatment over the traditional method, targeted delivery of anticancer agents using nanoparticles, influence of nanotechnology on the quality and expectancy of life, and challenges, implications and future prospects of metallic nanoparticles as probes in cancer treatment.
The development of metallic nanoparticles is rapid and multidirectional, and the improved practical potential of metallic nanoparticle highlights their potency as new tools for future cancer therapeutics modalities.
将治疗剂靶向递送到肿瘤细胞是一个挑战，因为大多数化疗药物会分布到全身，这会导致全身毒性和患者的接受程度差，有时甚至会停止治疗。金属纳米粒子在医学治疗的各个领域已经被广泛应用于大量的应用中。金属纳米粒子作为癌症治疗的新型载体和对比剂正在兴起。这些金属纳米粒子已被用于通过主动和被动靶向对肿瘤细胞进行成像。最近的进展为这些纳米粒子的靶向和药物递释开辟了道路。
本篇综述总结了金属纳米粒子通过被动和主动靶向进行药物递释的机制，以及它们在癌症治疗中的潜在应用。
读者将了解肿瘤细胞的发展、现代癌症治疗方法相对于传统方法的优势、使用纳米粒子进行抗癌药物的靶向递释、纳米技术对生活质量和预期寿命的影响，以及金属纳米粒子作为癌症治疗探针的挑战、影响和未来前景。
金属纳米粒子的发展迅速且多方向，金属纳米粒子的实际应用潜力得到提高，突出了它们作为未来癌症治疗新方法的潜力。
