Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.
Endocr J. 2012;59(1):21-9. doi: 10.1507/endocrj.ej11-0023. Epub 2011 Oct 12.
We aimed to evaluate plasma plasminogen activator inhibitor-1 (PAI-1) antigen levels in women with polycystic ovary syndrome (PCOS) and different levels of adiposity and PCOS phenotypes. We studied 199 women with PCOS and 50 age-matched healthy women divided in normal weight (n=100 and n=25, respectively) and overweight/obese (n=99 and n=25, respectively). Normal weight and overweight/obese patients with PCOS were further divided in patients diagnosed according to the 1990 criteria (i.e. with anovulation and hyperandrogenemia; 1990 criteria group) and in patients with the additional phenotypes introduced in 2003 (i.e. with polycystic ovaries and either anovulation or hyperandrogenemia; additional 2003 criteria group). In normal weight subjects, plasma PAI-1 levels did not differ between women with PCOS (regardless of group) and controls, or between the 1990 criteria and the additional 2003 criteria groups of PCOS. In overweight/obese subjects, plasma PAI-1 levels were higher in both the 1990 criteria and the additional 2003 criteria groups of PCOS compared with controls (p<0.001 and p=0.004, respectively), but did not differ between the 1990 criteria and the additional 2003 criteria groups of PCOS. In conclusion, plasma PAI-1 levels are elevated in overweight/obese women with PCOS but not in normal weight women with this syndrome. Plasma PAI-1 levels do not differ between the phenotypes of PCOS.
我们旨在评估多囊卵巢综合征（PCOS）女性中血浆纤溶酶原激活物抑制剂-1（PAI-1）抗原水平，以及不同肥胖程度和 PCOS 表型的 PAI-1 抗原水平。我们研究了 199 名多囊卵巢综合征女性和 50 名年龄匹配的健康女性，分为正常体重（分别为 n=100 和 n=25）和超重/肥胖（分别为 n=99 和 n=25）。正常体重和超重/肥胖的 PCOS 患者进一步分为根据 1990 年标准诊断的患者（即排卵障碍和高雄激素血症；1990 年标准组）和 2003 年引入的附加表型的患者（即多囊卵巢和排卵障碍或高雄激素血症；附加 2003 年标准组）。在正常体重受试者中，无论 PCOS 患者是否属于任何组别（1990 年标准组和附加 2003 年标准组），其血浆 PAI-1 水平与对照组相比均无差异，1990 年标准组和附加 2003 年标准组之间也无差异。在超重/肥胖受试者中，无论属于哪一组，1990 年标准组和附加 2003 年标准组的 PCOS 患者的血浆 PAI-1 水平均高于对照组（分别为 p<0.001 和 p=0.004），但两组之间无差异。综上所述，超重/肥胖的 PCOS 女性的血浆 PAI-1 水平升高，但正常体重的 PCOS 女性无此变化。不同表型的 PCOS 患者之间的血浆 PAI-1 水平无差异。
