多囊卵巢综合征患者妊娠早期凝血和纤溶指标：初步研究。
Coagulation and fibrinolytic indices during the first trimester of pregnancy in women with polycystic ovary syndrome: a preliminary study.
机构信息
1Obstetrics and Gynecology Department of Navy General Hospital of Chinese PLA, Beijing, China.
出版信息
Reprod Sci. 2013 Nov;20(11):1390-7. doi: 10.1177/1933719113485293. Epub 2013 Apr 12.
OBJECTIVE
To evaluate the levels of coagulation and fibrinolytic markers during the first trimester of pregnancy in women with polycystic ovary syndrome (PCOS) and determine the effects of PCOS and obesity on the levels of these hemostatic markers.
METHODS
A cross-sectional study was conducted in Beijing, China, on women with PCOS (n = 50), healthy women (n = 50), pregnant women with PCOS (n = 50), and healthy pregnant women (n = 50) at 12 weeks of pregnancy. Coagulation and fibrinolytic parameters were measured.
RESULTS
The interaction between PCOS and pregnancy appears to exert effects on the activities of coagulation factors VIII and X. The interaction between PCOS and obesity also seems to affect the level of von Willebrand factor.
CONCLUSIONS
Pregnant women with PCOS, especially women who are obese, are observed to be in a more prohemostatic state during the first trimester.
目的
评估多囊卵巢综合征（PCOS）患者妊娠早期凝血和纤溶标志物的水平，并确定 PCOS 和肥胖对这些止血标志物水平的影响。
方法
在中国北京进行了一项横断面研究，纳入了 PCOS 患者（n=50）、健康女性（n=50）、妊娠合并 PCOS 患者（n=50）和健康妊娠女性（n=50），分别在妊娠 12 周时测量凝血和纤溶参数。
结果
PCOS 和妊娠之间的相互作用似乎会影响凝血因子 VIII 和 X 的活性。PCOS 和肥胖之间的相互作用也似乎会影响血管性血友病因子的水平。
结论
妊娠合并 PCOS 的女性，尤其是肥胖女性，在妊娠早期更倾向于高凝状态。
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