Takagi Kosei, Kawamoto Kazuyuki, Ikeda Hiroyoshi, Itoh Tadashi
Dept. of Surgery, Kurashiki Central Hospital.
Gan To Kagaku Ryoho. 2011 Jun;38(6):1025-7.
The patient was a 70-year-old male who had multiple lung metastases of rectal cancer. He was administered UFT(300mg/ day)and LV(75mg/day)after Hartmann operation for rectal cancer. He complained of fever and difficulty breathing after 2 courses of these medicines, and was admitted for UFT-and LV-induced interstitial pneumonitis. Treatment with methylpredni- solone(30mg/day)improved his symptoms and revealed radical findings. He was ready for discharge on the 10th day after treatment. Interstitial pneumonitis-induced UFT and LV is rare, but can lead to severe complications, which should be diagnosed and treated by corticosteroid as soon as possible.
该患者为一名70岁男性，患有直肠癌多发肺转移。在直肠癌Hartmann手术后，他接受了优福定（300毫克/天）和亚叶酸钙（75毫克/天）治疗。服用这两种药物两个疗程后，他出现发热和呼吸困难症状，并因优福定和亚叶酸钙诱发的间质性肺炎入院。使用甲泼尼龙（30毫克/天）治疗后症状改善，检查结果显示病情好转。治疗后第10天他已准备好出院。优福定和亚叶酸钙诱发的间质性肺炎较为罕见，但可导致严重并发症，应尽早用皮质类固醇进行诊断和治疗。
