Takada Atsushi, Kawahara Masaki, Kobayashi Hiroaki, Takino Youko, Kodama Takashi, Sugishita Takeo, Ohno Yasuo, Oka Teruaki, Tsukamoto Fumihito
Dept. of Surgery, Kanto Central Hospital.
Gan To Kagaku Ryoho. 2012 Jun;39(6):997-9.
We report a case of complete remission after treatment with tegafur-uracil (UFT)/Leucovorin (LV) therapy for pulumonary metastasis of rectal cancer. A 56-year-old male was admitted to our hospital with a diagnosis of rectal cancer (Ra, type2). Chest CT on admission demonstrated bilateral lung metastases (rt S2 and lt S4). After anterior resection of the primary tumor, oral UFT/LV was administered (UFT 400 mg/LV 75 mg, 4-week administration and 1-week no-administration period) on an outpatient basis. After 2 courses, chest CT revealed reduction of both metastases, and complete resection of the metastases by video assisted thoracic surgery (VATS) was planned. Pathological findings of a specimen revealed no residual cancer cells, indicating a complete response to UFT/LV therapy. After these treatments, combined therapy of UFT/LV was continued for 3 months, and the single administration of UFT was continued for 1 year. The patient experienced no adverse reactions, and has had no recurrent disease in 4 years. Oral UFT/LV therapy is considered to be a promising regimen for patients with resectable metastatic lesion from a standpoint of clinical efficacy and safety.
我们报告了1例经替加氟-尿嘧啶（UFT）/亚叶酸钙（LV）治疗后直肠癌肺转移完全缓解的病例。一名56岁男性因诊断为直肠癌（Ra，2型）入住我院。入院时胸部CT显示双侧肺转移（右肺S2和左肺S4）。原发肿瘤前切除术后，门诊给予口服UFT/LV（UFT 400 mg/LV 75 mg，给药4周，停药1周）。2个疗程后，胸部CT显示转移灶均缩小，并计划通过电视辅助胸腔镜手术（VATS）对转移灶进行完全切除。标本的病理检查结果显示无残留癌细胞，表明对UFT/LV治疗完全缓解。经过这些治疗后，继续UFT/LV联合治疗3个月，继续单药服用UFT 1年。患者未出现不良反应，4年内无疾病复发。从临床疗效和安全性的角度来看，口服UFT/LV治疗被认为是有可切除转移灶患者的一种有前景的治疗方案。
