Ueda Shiro, Minami Yoshihiko, Hara Yasuhito, Kawano Takahiro, Tominaga Tamaki
Department of Surgery, Ohyodo General Hospital, Japan.
Gan To Kagaku Ryoho. 2011 Oct;38(10):1709-11.
We report a case of synchronous multiple liver metastases of rectal cancer successfully treated with tegafur/uracil(UFT) and oral Leucovorin (LV) chemotherapy. Lower anterior resection was carried out on the rectal cancer patient (an 80-year- old man), who had synchronous multiple liver metastases. The UFT (450 mg/day) and oral LV (75 mg/day) were orally administered for 4 weeks, followed by a 1-week interval after the surgical procedure. After completion of 16 courses, CT scan showed no liver metastases, and the patient was judged to have achieved a complete response (CR). The interval of CR was maintained for sixteen months until the age of 82. This chemotherapy is expected to have a potent therapeutic efficacy for older adult patients with advanced rectal cancer, because it is convenient and causes no severe diverse events.
我们报告了一例直肠癌同步多发肝转移患者成功接受替加氟/尿嘧啶（UFT）和口服亚叶酸钙（LV）化疗的病例。对一名患有同步多发肝转移的直肠癌患者（一名80岁男性）进行了低位前切除术。术后，口服UFT（450毫克/天）和口服LV（75毫克/天）4周，然后间隔1周。完成16个疗程后，CT扫描显示无肝转移，患者被判定为达到完全缓解（CR）。CR期维持了16个月，直至患者82岁。这种化疗方法方便且不会引起严重的不良反应，有望对老年晚期直肠癌患者产生有效的治疗效果。
