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[联邦德国和民主德国的血压与相对体重、酒精摄入量及电解质排泄:国际盐类摄入与血压关系研究。联邦德国和民主德国的国际盐类摄入与血压关系研究小组]

[Blood pressure and relative body weight, alcohol consumption and electrolyte excretion in the FRG and the GDR: the Intersalt Study. The Intersalt Study Group form the FRG and the GDR].

出版信息

Klin Wochenschr. 1990 Jul 5;68(13):655-63.

PMID:2199722
Abstract

The relationships between body mass index (BMI) and age, alcohol consumption, 24-hr urinary electrolyte excretion, and BP were studied in 588 subjects from three German centers participating in Intersalt, a highly standardized, previously reported protocol. Men and women aged 20-59 were sampled in Bernried, FRG; Cottbus, GDR; and Heidelberg, FRG. The subjects from the three centers did not differ in BMI, level of education, physical activity, cigarette- or alcohol-consumption patterns, or urinary Cl excretion. Mean Na excretion was 167, 147, and 172 mmol/24 hr in Bernried, Cottbus, and Heidelberg, while mean K excretion was 72, 55, and 73 mmol/24 hr, respectively. The excretion of these electrolytes was significantly lower in Cottbus than in Bernried or Heidelberg. BMI increased progressively in men with age; in women BMI plateaued until the 5th decade, after which it increased to equal that of men. In individual centers, the excretion of electrolytes was correlated with BMI. Sodium and chloride excretion were highly correlated. The data from each individual center were fitted to a multiple regression model. Age, BMI, sex, and alcohol consumption entered the model.

摘要

在来自德国三个中心的588名受试者中,研究了体重指数(BMI)与年龄、饮酒量、24小时尿电解质排泄量和血压之间的关系。这些受试者参与了“国际盐与血压研究”(Intersalt),这是一个高度标准化且先前已报道过的研究方案。20至59岁的男性和女性分别来自联邦德国的伯恩里德、民主德国的科特布斯以及联邦德国的海德堡。来自这三个中心的受试者在BMI、教育水平、身体活动、吸烟或饮酒模式以及尿氯排泄方面并无差异。伯恩里德、科特布斯和海德堡的平均钠排泄量分别为167、147和172 mmol/24小时,而平均钾排泄量分别为72、55和73 mmol/24小时。科特布斯的这些电解质排泄量显著低于伯恩里德或海德堡。男性的BMI随年龄逐渐增加;女性的BMI在50岁之前趋于平稳,之后开始上升并与男性持平。在各个中心,电解质排泄量与BMI相关。钠和氯的排泄量高度相关。每个中心的数据都被拟合到一个多元回归模型中。年龄、BMI、性别和饮酒量被纳入该模型。

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