J Hypertens Suppl. 1988 Dec;6(4):S584-6.
INTERSALT is a multicentre epidemiological study of electrolyte excretion and blood pressure. The 10,079 participants, aged 20-59 years, were sampled from 52 centres around the world, and data were collected according to a strict protocol and with extensive quality control. The relationships between blood pressure and 24-h urinary sodium and potassium excretion, body mass index and alcohol intake were assessed both in individuals and across centres. The individual analyses, with adjustment for confounding variables, showed highly significant positive associations between blood pressure and sodium excretion, the sodium/potassium ratio, body mass index and high alcohol intake, and a significant negative association between blood pressure and potassium excretion. In the inter-centre analyses, sodium was significantly related to the slope of blood pressure with age, but not to median blood pressure. Other intercentre results were inconsistent.
国际食盐与血压关系研究（INTERSALT）是一项关于电解质排泄与血压的多中心流行病学研究。10079名年龄在20至59岁之间的参与者来自全球52个中心，数据收集严格按照方案进行，并经过广泛的质量控制。在个体层面和各中心之间评估了血压与24小时尿钠和钾排泄、体重指数以及酒精摄入量之间的关系。个体分析在对混杂变量进行调整后显示，血压与钠排泄、钠/钾比值、体重指数以及高酒精摄入量之间存在高度显著的正相关，而血压与钾排泄之间存在显著的负相关。在中心间分析中，钠与血压随年龄变化的斜率显著相关，但与血压中位数无关。其他中心间结果并不一致。
