肾脏水盐调节的分子生物学
Molecular biology of water and salt regulation in the kidney.
机构信息
Renal Unit and Hypertension, Fundació Puigvert, Universitat Autònoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Instituto de Investigación Biomédica Sant Pau, Cartagena 340-350, 08025 Barcelona, Spain.
出版信息
Cell Mol Life Sci. 2012 Mar;69(5):683-95. doi: 10.1007/s00018-011-0858-4. Epub 2011 Oct 14.
Abstract
The kidney plays a central role in the regulation of the salt and water balance, which depends upon an array of solute and water transporters in the renal tubules and upon vascular elements in the various regions of the kidney. Many recent studies have improved our understanding of this process. In this review, we summarize the current data on the molecules involved in sodium and water transport in the renal tubules, focusing in particular on aquaporins and renal sodium transporters and channels.
摘要
肾脏在调节盐和水平衡方面起着核心作用，这取决于肾脏小管中的一系列溶质和水转运体以及肾脏各个区域的血管成分。许多最近的研究提高了我们对这一过程的理解。在这篇综述中，我们总结了目前关于肾脏小管中钠和水转运分子的研究数据，特别关注水通道蛋白和肾脏钠转运体和通道。
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2
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J Am Soc Nephrol. 2011 Apr;22(4):605-14. doi: 10.1681/ASN.2010080827. Epub 2011 Mar 24.
3
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Mol Cell Proteomics. 2011 Jan;10(1):M110.004036. doi: 10.1074/mcp.M110.004036. Epub 2010 Oct 12.
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