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本文引用的文献

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Novel mechanisms for NaCl reabsorption in the collecting duct.集合管中 NaCl 重吸收的新机制。
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2
The WNK kinase network regulating sodium, potassium, and blood pressure.WNK 激酶网络调节钠、钾和血压。
J Am Soc Nephrol. 2011 Apr;22(4):605-14. doi: 10.1681/ASN.2010080827. Epub 2011 Mar 24.
3
SPAK and WNK kinases: a new target for blood pressure treatment?SPAK 和 WNK 激酶:血压治疗的新靶点?
Curr Opin Nephrol Hypertens. 2011 Jan;20(1):16-22. doi: 10.1097/MNH.0b013e32834132bc.
4
Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells.定量蛋白质和 mRNA 谱分析显示,加压素在肾细胞中对蛋白质表达具有选择性的转录后调控。
Mol Cell Proteomics. 2011 Jan;10(1):M110.004036. doi: 10.1074/mcp.M110.004036. Epub 2010 Oct 12.
5
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction.SPAN11 敲除小鼠表现出 Gitelman 综合征和血管收缩功能障碍。
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SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.SORLA/SORL1 与 SPAK 相互作用,共同调控肾脏钠钾氯协同转运蛋白 2 的激活。
Mol Cell Biol. 2010 Jun;30(12):3027-37. doi: 10.1128/MCB.01560-09. Epub 2010 Apr 12.
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Regulation of the epithelial sodium channel (ENaC) by membrane trafficking.通过膜转运对上皮钠通道(ENaC)进行调控。
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Aquaporins in kidney pathophysiology.水通道蛋白在肾脏病理生理学中的作用。
Nat Rev Nephrol. 2010 Mar;6(3):168-78. doi: 10.1038/nrneph.2009.231. Epub 2010 Jan 26.

肾脏水盐调节的分子生物学

Molecular biology of water and salt regulation in the kidney.

机构信息

Renal Unit and Hypertension, Fundació Puigvert, Universitat Autònoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Instituto de Investigación Biomédica Sant Pau, Cartagena 340-350, 08025 Barcelona, Spain.

出版信息

Cell Mol Life Sci. 2012 Mar;69(5):683-95. doi: 10.1007/s00018-011-0858-4. Epub 2011 Oct 14.

DOI:10.1007/s00018-011-0858-4
PMID:21997386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11114984/
Abstract

The kidney plays a central role in the regulation of the salt and water balance, which depends upon an array of solute and water transporters in the renal tubules and upon vascular elements in the various regions of the kidney. Many recent studies have improved our understanding of this process. In this review, we summarize the current data on the molecules involved in sodium and water transport in the renal tubules, focusing in particular on aquaporins and renal sodium transporters and channels.

摘要

肾脏在调节盐和水平衡方面起着核心作用,这取决于肾脏小管中的一系列溶质和水转运体以及肾脏各个区域的血管成分。许多最近的研究提高了我们对这一过程的理解。在这篇综述中,我们总结了目前关于肾脏小管中钠和水转运分子的研究数据,特别关注水通道蛋白和肾脏钠转运体和通道。