Ercoli L, Perno C F, Bergamini A, Rocchi G
Dipartimento di Sanità Pubblica e Biologia Cellulare, Università degli Studi di Roma, Tor Vergata.
Medicina (Firenze). 1990 Jan-Mar;10(1):1-8.
The pathogenesis of HIV infection and the definition of the cell types target of HIV is the crucial background for the improvement of the therapeutic strategies against HIV infection. Monocyte-macrophages (M/M) are easily infected by HIV, and play a crucial role in the maintenance and the progression of HIV-related disease; HIV infection of M/M is the principal cause of HIV-related "dementia complex". Thus it is crucial that drugs used in the therapy of HIV infection are active against HIV replicating in cells of M/M lineage. In this paper the interaction between HIV and M/M is analyzed and the characteristics of viral replication in these cells, and the in vitro antiviral activity of several drugs in M/M are discussed. These data suggest that patients should be treated with drugs, that inhibit HIV also in M/M and, consequently, are able to block the clinical manifestations related to M/M infection, such as "dementia complex".
HIV感染的发病机制以及HIV靶向的细胞类型的定义是改进抗HIV感染治疗策略的关键背景。单核细胞-巨噬细胞（M/M）很容易被HIV感染，并且在HIV相关疾病的维持和进展中起关键作用；M/M的HIV感染是HIV相关“痴呆综合征”的主要原因。因此，用于治疗HIV感染的药物对在M/M谱系细胞中复制的HIV具有活性至关重要。本文分析了HIV与M/M之间的相互作用、这些细胞中病毒复制的特征，并讨论了几种药物在M/M中的体外抗病毒活性。这些数据表明，应该用能在M/M中也抑制HIV的药物治疗患者，从而能够阻断与M/M感染相关的临床表现，如“痴呆综合征”。
