San Giovanni di Dio Hospital, University of Cagliari, Cagliari, Italy.
Ultrasound Obstet Gynecol. 2012 May;39(5):581-6. doi: 10.1002/uog.10120.
To describe the gray-scale and color Doppler ultrasound features as well as some clinical and biochemical features of metastatic ovarian tumors according to the origin of the primary tumor in a large study population,
This was a retrospective analysis of 116 masses in 92 patients (mean age, 51 years) evaluated and treated at three European university centers for a metastatic tumor in the ovary. All patients had undergone transvaginal color Doppler ultrasound according to a standardized protocol prior to surgery and tumor removal. Ultrasound features analyzed were bilaterality, tumor volume, morphologic gray-scale appearance and color score. CA 125 was also recorded.
Primary tumor histological diagnosis was as follows: colon-sigmoid (n = 32), stomach (n = 28), breast (n = 20), uterus (n = 17), lymphoma (n = 4), liver-pancreas-biliary tract (n = 4) and miscellaneous (n = 11). There were no differences in age, menopausal status or CA 125 values according to origin of primary tumor. Bilaterality was significantly more frequent in stomach metastases (56%) in comparison with colon-sigmoid and liver-pancreas-biliary tract metastases (18.5% and 0%, respectively, P < 0.05). Median tumor volume was significantly lower in breast metastases (33.5 mL) compared with other metastases (P < 0.05) except stomach metastases and metastatic tumors from the miscellaneous group. Ovarian metastases from breast cancers were significantly more frequently solid in comparison to stomach, colorectal and uterine cancer metastases (95.0% vs. 60.8%, 46.8% and 70.6%, respectively, P < 0.05), and tended to appear moderately or highly vascularized. There were no differences in color score among all groups, although the percentage of masses with abundant color was high (50-82%).
Ovarian metastases derived from breast cancers tend to be small, solid and vascularized; they seem to be the only ovarian metastases whose primary tumor origin can be suspected by ultrasonography preoperatively. Color score does not seem to help suspect the origin of the primary tumor.
根据原发肿瘤的来源，描述大量研究人群中转移性卵巢肿瘤的灰阶和彩色多普勒超声特征以及一些临床和生化特征。
这是对在欧洲三个大学中心因卵巢转移性肿瘤而接受评估和治疗的 92 名患者的 116 个肿块进行的回顾性分析（平均年龄 51 岁）。所有患者均在手术和肿瘤切除前按照标准化方案进行经阴道彩色多普勒超声检查。分析的超声特征包括双侧性、肿瘤体积、形态灰阶外观和彩色评分。还记录了 CA 125。
原发肿瘤组织学诊断如下：结肠-乙状结肠（n=32）、胃（n=28）、乳腺（n=20）、子宫（n=17）、淋巴瘤（n=4）、肝-胰腺-胆道（n=4）和其他（n=11）。根据原发肿瘤的来源，患者的年龄、绝经状态或 CA 125 值均无差异。与结肠-乙状结肠和肝-胰腺-胆道转移相比，胃转移的双侧性明显更为常见（56%比 18.5%和 0%，P<0.05）。与其他转移相比，乳腺转移的肿瘤体积中位数明显较小（33.5 毫升）（P<0.05），但胃转移和来自其他组的转移性肿瘤除外。与胃、结直肠癌和子宫癌转移相比，乳腺癌引起的卵巢转移明显更常为实性（95.0%比 60.8%、46.8%和 70.6%，P<0.05），并且倾向于表现出中度或高度血管化。在所有组之间，彩色评分没有差异，尽管丰富彩色的肿块百分比很高（50-82%）。
来源于乳腺的卵巢转移倾向于小、实性和血管化；它们似乎是唯一可以通过术前超声怀疑其原发肿瘤来源的卵巢转移。彩色评分似乎无助于怀疑原发肿瘤的来源。
