耗散 DNA 甲基化：氧依赖性 DNA 去甲基化的新证据。
Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation.
机构信息
Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany.
出版信息
Chembiochem. 2011 Nov 25;12(17):2543-5. doi: 10.1002/cbic.201100549. Epub 2011 Oct 13.
PMID:21998074
Abstract
Where do you stop? Three recent publications have described how the oxidation of 5-methylcytosine by Tet dioxygenases does not stop at the 5-hydroxymethylcytosine (5hmC) state, rather further oxidation of 5hmC is involved in DNA demethylation. The nature of the enzymes involved in this process shed light on the dynamics of epigenetic signaling and its evolutionary origin.
摘要
有三篇最近的出版物描述了 TET 双加氧酶对 5-甲基胞嘧啶的氧化作用如何不会停留在 5-羟甲基胞嘧啶（5hmC）状态，而是进一步氧化 5hmC 参与 DNA 去甲基化。涉及该过程的酶的性质揭示了表观遗传信号的动态及其进化起源。
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